Incorporating Biomarkers into 21st Century Risk Assessments

Details

• Personal Author:
  DeBord, D. Gayle ; Maier A ; Savage RE
• Description:
  In 1987, the National Research Council Board on Environmental Studies and Toxicology defined a biologic marker as any cellular or molecular indicator of toxic exposure, adverse health outcome or susceptibility. Since that time, significant advances in molecular biology and analytical chemistry have lead to the use of these biomarkers in both molecular epidemiology and toxicology studies, providing the potential to integrate the results of two disciplines, which ordinarily evaluate health outcomes at population and organism levels respectively. Tempered success in molecular epidemiology studies has evoked the call for employing biomarkers in the risk assessment process. The identification, development and validation of biomarkers for use in environmental and human health assessments have tremendous potential to improve the quality and reduce uncertainty in risk estimates. However, application of biomarker methodologies across disciplines and incorporation within risk assessment processes is inherently complex and difficult. The potential benefits of such a merger are significant. We discuss a number of issues relevant to the successful incorporation of biomarkers into the risk assessment process. [Description provided by NIOSH]
• Subjects:
  Biomarkers Chemistry Chemistry, Analytic Occupational Health Risk Assessment Safety
• Keywords:
  Analytical-chemistry Analytical-processes Author Keywords: Biomarkers Risk-analysis Risk Assessment
• ISSN:
  0886-5140
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  7
• Issue:
  5
• NIOSHTIC Number:
  nn:20021804
• Citation:
  Comment Toxicol 2001 Sep; 7(5-6):519-539
• Contact Point Address:
  Andrew Maier, Toxicology Excellence for Risk Assessment (TERA), 1757 Chase Avenue, Cincinnati, OH 45223
• Email:
  maier@tera.org
• Federal Fiscal Year:
  2001
• Peer Reviewed:
  False
• Source Full Name:
  Comments on Toxicology: A Journal of Critical Discussion of the Current Literature
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ab4718795945a37df0a31bb50608bc33b2cd43210378e156c3783396bce805b82db4ad2d459206c0ac04fc0f777334f7f2c9ce50723b92f176a3d131ac001508
• Download URL:
  https://stacks.cdc.gov/view/cdc/198909/cdc_198909_DS1.pdf
• File Type:
  [PDF - 371.08 KB ]