Combining Drosophila melanogaster Somatic-Mutation-Recombination and Electron-Spin-Resonance-Spectroscopy Data to Interpret Epidemiologic Observations on Chromium Carcinogenicity

Details

• Personal Author:
  Beaubier J ; Chiu A ; Katz AJ ; Shi X
• Description:
  Lung cancers are significantly increased among workers exposed to chromate (Cr6+, Cr3+), chromium pigments (Cr6+) and chromium plating (Cr6+). Chromium lung burdens and cancer risk increase proportionately with duration of employment at long latencies. However, this epidemiologic information alone is insufficient in determining whether Cr6+ or Cr3+ are equally important in causing cancer. We have attempted to combine epidemiologic data with data from the Drosophila melanogaster somatic-mutation-recombination-test and from the in vitro electron-spin-resonance spectroscopy study to demonstrate that following somatic recombination plays a more important role than somatic mutation in chromium carcinogenesis. Cr4+ is more important than Cr5+ or Cr6+ in inducing somatic recombination while Cr6+ produces more and bigger clones than Cr4+ in somatic mutation. Cr3+ produces negative results in this fruit-fly wing-spot-assay. When the larvae and flies exposed to Cr6+ and Cr4+ are examined by ESR, only Cr5+ and Cr3+ are found. Thermodynamic parameters deltaE, deltaH, and deltaS are also estimated from these latter experiments to explain the relative importance of Cr6+, Cr4+, Cr3+ in chromium carcinogenesis among exposed industrial workers. [Description provided by NIOSH]
• Subjects:
  Carcinogens Chromates Chromium Epidemiology Lung Lung Diseases Neoplasms Occupational Exposure Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety

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• Keywords:
  Author Keywords: Fruit Fly Cancer Carcinogenesis Carcinogenicity Chrome-plating Chromium-compounds Chromium Carcinogenicity Electron-spin-resonance-spectroscopy Epidemiolog Exposure-levels In-vitro-studies Lung-burden Lung-cancer Occupational-exposure Pulmonary-system-disorders Respiratory-system-disorders Risk-analysis Risk-factors Somatic-mutation-recombination Test Workers

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• ISSN:
  0300-8177
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  District of Columbia ; Illinois ; OSHA Region 3 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  61-68
• Volume:
  222
• Issue:
  1
• NIOSHTIC Number:
  nn:20021768
• Citation:
  Mol Cell Biochem 2001 Jun; 222(1-2):61-68
• Email:
  xas0@cdc.gov
• CAS Registry Number:
  Chromium (CAS RN 7440-47-3)
• Federal Fiscal Year:
  2001
• Peer Reviewed:
  True
• Source Full Name:
  Molecular and Cellular Biochemistry
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:67877865146ddbc5de6e817982844182009bb54a26334efd62452fd2c3c64bc2accb804b45af0fc791f7328dbc2c3ef978aeabe41254ce9397c7b5b6fbc0b200
• Download URL:
  https://stacks.cdc.gov/view/cdc/198877/cdc_198877_DS1.pdf
• File Type:
  [PDF - 81.16 KB ]