Iron Tetrakis (N-Methyl-4′-Pyridyl) Porphyrinato (FeTMPyP) Is a Potent Scavenging Antioxidant and an Inhibitor of Stimulant-Induced NF-kB Activation of Raw 264.7 Macrophages

Details

• Personal Author:
  Castranova, Vincent ; Kang JL ; Lee HS ; Leonard, Stephanie ; Pack IS
• Description:
  Metalloporphyrins have been shown to be protective in oxidative stress models. However, the molecular basis for the antioxidative and antiinflammatory activities of iron tetrakis (N-methyl-4'-pyridyl) porphyrinato (FeTMPyP) is not known. The objective of this study was to determine whether FeTMPyP exhibited the ability to (1) scavenge reactive oxygen species (ROS), (2) inhibit the activation of nuclear factor kappa B (NF-kappaB), or (3) block the production of interleukin 1 (IL-1) in RAW 264.7 cultured macrophages. The results indicate that FeTMPyP is a potent scavenger of hydroxyl radicals and superoxide anion radicals, and an effective inhibitor of stimulant-induced NF-kappaB activation and IL-1 production by RAW 264.7 cells. Therefore, FeTMPyP may be a useful tool to investigate the molecular mechanisms involved in stimulant-induced signal pathways, and may possess therapeutic utility in diseases associated with overproduction of ROS. [Description provided by NIOSH]
• Subjects:
  Antioxidants Occupational Health Safety
• Keywords:
  Diseases Metalloporphyrins Models Stress
• ISSN:
  1528-7394
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  291-310
• Volume:
  64
• Issue:
  4
• NIOSHTIC Number:
  nn:20021766
• Citation:
  J Toxicol Environ Health A 2001 Oct; 64(4):291-310
• Contact Point Address:
  Dr. Jihee Lee Kang, Department of Physiology, College of Medicine, Ewha Womans University, 911-1 Mok-6-dong, Yangcheon-ky, Seoul 158-056, Korea
• Email:
  Jihee@mm.ewha.ac.kr
• Federal Fiscal Year:
  2002
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Toxicology and Environmental Health, Part A: Current Issues
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a36f1d6b170c4c2fc9fd2f1c3ae1fb3464f55a38591b3c8f29c78a1ec1f4e3427ea21efd7b61cf1a22a0012f73ae44e494c194d3b131d074ab7738b64717e987
• Download URL:
  https://stacks.cdc.gov/view/cdc/198875/cdc_198875_DS1.pdf
• File Type:
  [PDF - 630.28 KB ]