Antioxidant Mechanisms of Nitric Oxide Against Iron-Catalyzed Oxidative Stress in Cells

Details

• Personal Author:
  Kagan VE ; Kozlov AV ; Shvedova AA ; Tyurina YY ; Yalowich JC
• Description:
  Three distinct antioxidant pathways are considered through which iron-catalyzed oxidative stress may be regulated by nitric oxide (NO). The first two pathways involve direct redox interactions of NO with iron catalytic sites and represent a fast response that may be considered an emergency mechanism to protect cells from the consequences of acute and intensive oxidative stress. These are (i) NO-induced nitrosylation at heme and non-heme iron catalytic sites that is capable of directly reducing oxoferryl-associated radicals, (ii) formation of nitrosyl complexes with intracellular "loosely" bound redox-active iron, and (iii) an indirect regulatory pathway that may function as an adaptive mechanism that becomes operational upon long-term exposure of cells to NO. In the latter pathway, NO down-regulates expression of iron-containing proteins to prevent their catalytic prooxidant reactions. [Description provided by NIOSH]
• Subjects:
  Antioxidants Occupational Health Safety
• Keywords:
  Exposure-levels Iron-oxides Oxidative-processes Oxides Proteins Reaction-rates Stress
• ISSN:
  1523-0864
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  189-202
• Volume:
  3
• Issue:
  2
• NIOSHTIC Number:
  nn:20021764
• Citation:
  Antioxid Redox Signal 2001 Apr; 3(2):189-202
• Contact Point Address:
  Dr. Valerian E. Kagan, Department of Environmental and Occupational Health, University of Pittsburgh, 260 Kappa Dr., RIDC Park, Pittsburgh, PA 15238, U.S.A.
• Email:
  kagan@pitt.edu
• Federal Fiscal Year:
  2001
• Peer Reviewed:
  True
• Source Full Name:
  Antioxidants & Redox Signaling
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:83039dbb8f8050dcd171f1f0aae637b011cccf90df7ba96ee13d692fda5ef701c0a231b3f2acd32d994373fb781fd0aab4c75e386c00319b63017dc699d7c77f
• Download URL:
  https://stacks.cdc.gov/view/cdc/198873/cdc_198873_DS1.pdf
• File Type:
  [PDF - 279.29 KB ]