Hyperthyroidism Increases the Risk of Ozone-Induced Lung Toxicity in Rats

Details

• Personal Author:
  Brumbaugh K ; Frazer DG ; Goldsmith WT ; Huffman LJ ; Judy DJ ; McKinney WG ; Reynolds JS
• Description:
  The risk of lung injury from ozone exposure has been well documented. It is also known that various factors may significantly influence the susceptibility of animals to the toxic effects of ozone. In the present study, we investigated the possibility that hyperthyroidism might be associated with increases in ozone-induced pulmonary toxicity. To create a hyperthyroid condition, mature male Sprague--Dawley rats were given injections of thyroxine (dose range: 0.1 to 1 mg/kg body wt daily for 7 days). Control rats received vehicle injections. The animals were then exposed to air or ozone (dose range: 0.5 to 3 ppm for 3 h). At 18 h postexposure, bronchoalveolar lavage fluid and cells were harvested. In hyperthyroid animals, ozone exposure was associated with three- to sixfold increases in bronchoalveolar lavage fluid lactate dehydrogenase activities and albumin levels as well as the number of polymorphonuclear leukocytes harvested by bronchoalveolar lavage above levels observed in ozone-exposed control rats. Additional results from the present study suggest that these thyroid hormone-linked effects cannot be fully explained by differences in whole-body metabolic rate or changes in the inhaled dose of ozone. These findings indicate that the risk of ozone-induced lung toxicity is substantially increased in a hyperthyroid state and suggest that the susceptibility of the lung to damage from ozone exposure may be significantly influenced by individual thyroid hormone status. [Description provided by NIOSH]
• Subjects:
  Animals Environmental Monitoring Hazardous Substances Laboratories Lung Diseases Occupational Health Respiratory Tract Diseases Risk Assessment Risk Factors Safety
• Keywords:
  Animal-studies Author Keywords: Thyroxine Exposure-assessment Exposure-levels Laboratory-animals Lung-disorders Pulmonary-system-disorders Pulmonary Edema Rat Respiratory-system-disorders Risk-analysis Risk-factors Toxic-effects Toxins

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• ISSN:
  0041-008X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  18-26
• Volume:
  173
• Issue:
  1
• NIOSHTIC Number:
  nn:20021761
• Citation:
  Toxicol Appl Pharmacol 2001 May; 173(1):18-26
• Federal Fiscal Year:
  2001
• Peer Reviewed:
  True
• Source Full Name:
  Toxicology and Applied Pharmacology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:62bcbf225b7eddf0bf6fa63c0ecb4aa9aaf29fd4797f936b18b2845e89bafb3402ea4f3dff7f54f61cbf0f8a1fcb827fb4fc36a20961c9a3d277dd011300dfbe
• Download URL:
  https://stacks.cdc.gov/view/cdc/198870/cdc_198870_DS1.pdf
• File Type:
  [PDF - 100.87 KB ]