Interleukin-6 Treatment Augments Cutaneous Wound Healing in Immunosuppressed Mice

Details

• Personal Author:
  Berry Ann K ; Gallucci RM ; Luster MI ; Matheson JM ; Simeonova PP ; Sugawara T ; Yucesoy, Berran
• Description:
  It has been postulated that the inflammatory response that occurs after cutaneous wounding is a prerequisite for healing and that inflammatory cytokines, such as interleukin-6 (IL-6) are involved in this process. We showed previously that IL-6-deficient mice display delayed wound healing, which could be reversed by administration of a murine IL-6 expression plasmid or recombinant murine IL-6 (rMuIL-6). In the present study, we observed that delayed cutaneous wound healing, which occurs as a result of glucocorticoid-induced immunosuppression, can also be reversed by rMuIL-6, as evidenced by epithelialization, granulation tissue formation, and wound closure. In vehicle control mice, rMuIL-6 did not augment healing but rather delayed the process. Immunochemical studies indicated that the expression of matrix metalloproteinase-10 (MMP-10) was increased in dexamethasone-treated mice and that rMuIL-6 treatment reduced its expression, indicating that IL-6 may influence dermal matrix formation and, specifically, collagen synthesis. These results demonstrate that IL-6 can restore abnormal wound repair that occurs in immunodeficiency and suggest its use as a potential therapy. [Description provided by NIOSH]
• Subjects:
  Animals Ethanol Laboratories Occupational Health Safety
• Keywords:
  Animal-studies Biopsy Ethanols Injuries Laboratory-animals Statistical-analysis
• ISSN:
  1079-9907
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  21
• Issue:
  8
• NIOSHTIC Number:
  nn:20021735
• Citation:
  J Interferon Cytokine Res 2001 Aug; 21(8):603-609
• Federal Fiscal Year:
  2001
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Interferon & Cytokine Research
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:22c587e5aec7ac4231e2e4d8dd82dfdaea665521c721ae983a93f47ab4531bbc8c532d68b2ca3f86c6e2e7b485accd0894d403acbaa7ea64c0cf0ddd665dac52
• Download URL:
  https://stacks.cdc.gov/view/cdc/198845/cdc_198845_DS1.pdf
• File Type:
  [PDF - 383.54 KB ]