Exposure to Protein Aeroallergens in Egg Processing Facilities

Details

• Personal Author:
  Bernstein DI ; Biagini, Raymond E. ; Boeniger, Mark F. ; Lummus ZL ; Massoudi M ; Reed C ; Swanson MC
• Description:
  Proteinaceous materials in the air can be highly allergenic and result in a range of immunologically mediated respiratory effects, including asthma. We report on the largest evaluation of exposure to date of airborne egg protein concentrations in an egg breaking and processing plant that had cases of occupational asthma. Personal air samples for egg protein were analyzed in duplicate on each PTFE filter using two analytical methods: (1) a commercial assay for non-specific total protein, and (2) indirect competitive inhibition assay using an ELISA method to quantify specific egg protein components. The highest concentrations were found in the egg washing room (mean exposure 644 microg/m3) and breaking room (255 microg/m3), which were also the areas where the risk of being sensitized was the greatest. There was excellent quantitative agreement between the airborne concentrations of total protein and sum of the specific protein antigens (ovalbumin, ovomucoid, and lysozyme). The correlation coefficient of the log-transformed data from the two methods was 0.88 (p < 0.0001). Size-selective sampling also indicated that most of the aerosol was capable of reaching the small airways. The methods described can be utilized to evaluate employee exposure to egg proteins. Exposure documentation, coupled with recommended exposure reduction strategies, could facilitate prevention of future employee sensitization and allergic respiratory responses by identifying high-exposure jobs and evaluating control measures. [Description provided by NIOSH]
• Subjects:
  Aerosols Air Pollutants, Occupational Air Pollution, Indoor Environmental Exposure Environmental Monitoring Hypersensitivity Irritants Lung Lung Diseases Manufacturing And Industrial Facilities Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Aerosol-particles Air-contamination Air-sampling Airborne-particles Allergens Allergic-disorders Allergic-reactions Allergies Allergy Author Keywords: Egg Industrial-exposures Industrial-factory-workers Industrial-hazards Industrial-safety Occupational-health Occupational Asthma Occupational Exposure Protein Proteins Pulmonary-disorders Pulmonary-system-disorders Respiratory-irritants Respiratory-system-disorders Sensitization

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• ISSN:
  1047-322X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  16
• Issue:
  6
• NIOSHTIC Number:
  nn:20021677
• Citation:
  Appl Occup Environ Hyg 2001 Jun; 16(6):660-670
• Federal Fiscal Year:
  2001
• Peer Reviewed:
  True
• Source Full Name:
  Applied Occupational and Environmental Hygiene
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:36e6976c381eb83714d2ee3288f25b5be6b36e1f7fa4bea7a4d7683fec1d9873c56a1e9d189fe8c9017f6b83f06a20f7c3c3a76ffce33ae1f92ba724ec72ce30
• Download URL:
  https://stacks.cdc.gov/view/cdc/198805/cdc_198805_DS1.pdf
• File Type:
  [PDF - 1.48 MB ]