Obesity as a Potential Risk Factor for Dopaminergic Neurotoxicity

Details

• Personal Author:
  O'Callaghan JP ; Sriram K
• Description:
  Obesity is a major risk factor associated with a variety of human disorders. While its involvement in disorders such as diabetes, coronary heart disease and cancer have been well characterized; it remains to be determined if obesity has a detrimental effect on the nervous system. Due to the limited regenerative capability of the CNS and the specific vulnerability of certain cell types to disease and chemical injury, obesity may confer an added risk of damage to the brain as it does to other organ systems. To address this possibility we sought to determine whether obesity can mediate/modify the brain's response to neurotoxic insult. [Description provided by NIOSH]
• Subjects:
  Animals Hazardous Substances Laboratories Nervous System Nervous System Diseases Nervous System Disorders Occupational Health Risk Assessment Risk Factors Safety
• Keywords:
  Animal-studies Central-nervous-system-disorders Laboratory-animals Nervous-system-disorders Neurotoxic-effects Neurotoxicity Risk-analysis Risk-factors Toxic-effects
• ISSN:
  0161-813X
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  22
• Issue:
  6
• NIOSHTIC Number:
  nn:20021456
• Citation:
  Neurotoxicology 2001 Dec; 22(6):888
• Federal Fiscal Year:
  2002
• Peer Reviewed:
  False
• Source Full Name:
  Neurotoxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:24c879f46a3a7c7cb73f2f04e167ec63fd55fa7b2ed3a1ab6ed386b88fe06ce6627be63aec29ee4a91eba45bf88266ea37ec4419289817d1fd1340af46b3e6af
• Download URL:
  https://stacks.cdc.gov/view/cdc/198767/cdc_198767_DS1.pdf
• File Type:
  [PDF - 98.86 KB ]