Sensitive Early Indicators of Hepatic and Kidney Damage in Workers Exposed to Jet Fuel (JP-8)

Details

• Personal Author:
  Butler MA ; Clark JC ; Knecht EA ; Krieg EF Jr. ; Snawder, John E.
• Description:
  The study group represents a very healthy segment of the population. Sensitive measures for liver and kidney damage did not detect any adverse effects in specimens from this study group. Evidence of elevated creatinine in the mean post-shift samples of exposure category 3 was seen. However, while these values are within normal clinical ranges, they are consistent with concentrated urine indicative of mild dehydration. Because of the elevated urine creatinine levels in post-shift samples of exposure category 3, there is an apparent decrease in pre- vs. post-shift levels of Neph alpha- and pi-GST in these samples. This is an artifact of the concentrated creatinine. When levels of urinary GSTs are expressed on a per volume basis, levels remain unchanged between pre- and post-shift samples. [Description provided by NIOSH]
• Subjects:
  Biomarkers Occupational Health Safety
• Keywords:
  Air Force Personnel Exposure Jet Engine Fuels Jet Propellant Type 8 JP-8 Kidney Function Kidneys Liver Liver Enzymes Liver Function Physiology

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• Publisher:
  Air Force Institute for Operational Health
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  Ohio ; OSHA Region 5 ; OSHA Region 6 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  81-86
• NIOSHTIC Number:
  nn:20021453
• NTIS Accession Number:
  ADA-443114
• Citation:
  JP8: final risk assessment. Kendall RK, Smith E, eds. Brooks City-Base, TX: Air Force Institute for Operational Health, 2001 Aug; :81-86
• Editor(s):
  Kendall RK; Smith E
• Federal Fiscal Year:
  2001
• Peer Reviewed:
  False
• Source Full Name:
  JP8: final risk assessment
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0b0e0fac2889a6340e711eff05b299afdd9c09e2206239539c58fa0cb7ed2bf07f70f6fede0af2171a92df164de887a21eb1c3c43907dc43cdbd32f2b581e731
• Download URL:
  https://stacks.cdc.gov/view/cdc/198764/cdc_198764_DS1.pdf
• File Type:
  [PDF - 362.99 KB ]