Gene Environment Interactions and Exposure to JP-8 Jet Fuel

Details

• Personal Author:
  Butler MA ; Flugel CA ; Kesner JS ; Krieg EF Jr. ; Snawder, John E.
• Description:
  Final analysis of gene-environment interactions in the JP8 jet fuel study will be completed as soon as data are available on all outcome measures. Analysis will be simplified because results of the genotype analysis in the 316 participants have shown that there is no significant difference in distribution of genotypes across exposure categories. Exposure will be refined by including measures of dermal exposure and blood levels of JP8 jet fuel components. Gene environment interactions will be examined in the postural sway test, an assessment of a participant's control mechanism for governing balance and in the conditional eyeblink response, which can identify cognitive deficits. In addition, gene interactions will be evaluated in the GASH/BARS system that is designed to measure motivation, response speed, coordination, grip strength, complex mental functioning, memory, and attention. Furthermore, interactions with passive benzene and naphthalene exposure, exhaled and urinary benzene and naphthalene, and molecular adducts of naphthalene may be described. [Description provided by NIOSH]
• Subjects:
  Genetics Occupational Health Safety
• Keywords:
  Air Force Personnel Exposure Genes Jet Engine Fuels Jet Propellant Type 8 JP-8 Physiology
• Publisher:
  Air Force Institute for Operational Health
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  Ohio ; OSHA Region 5 ; OSHA Region 6 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  76-80
• NIOSHTIC Number:
  nn:20021268
• NTIS Accession Number:
  ADA-443114
• Citation:
  JP8: final risk assessment. Kendall RK, Smith E, eds. Brooks City-Base, TX: Air Force Institute for Operational Health, 2001 Aug; :76-80
• CAS Registry Number:
  Benzene (CAS RN 71-43-2) ; Naphthalene (CAS RN 91-20-3)
• Editor(s):
  Kendall RK; Smith E
• Federal Fiscal Year:
  2001
• Peer Reviewed:
  False
• Source Full Name:
  JP8: final risk assessment
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:56a549d2c485e6ad8fc3524c06339717d22d3977eb5f4343bf90664dd845b0fe4b02a468981829a2fdc3347051a2454bdbfeac0ab1979e86638ee242603d8f03
• Download URL:
  https://stacks.cdc.gov/view/cdc/198669/cdc_198669_DS1.pdf
• File Type:
  [PDF - 679.83 KB ]