Role of Nitric Oxide in Pathological Responses of the Lung to Exposure to Environmental/Occupational Agents

Details

• Personal Author:
  Castranova, Vincent ; Zeidler PC
• Description:
  Conflicting evidence exists as to whether nitric oxide expresses damaging/inflammatory or antioxidant/anti-inflammatory properties. Data presented in this review indicate that in vitro or in vivo exposure to selected environmental or occupational agents, such as asbestos, silica, ozone or lipopolysaccharide, can result in up-regulation of inducible nitric oxide synthase by alveolar macrophages and pulmonary epithelial cells. In the case of silica exposure, evidence consistently supports a damaging/inflammatory role of nitric oxide and/or peroxynitrite in the pathogenesis of lung disease. Although conflicting data have been reported, the majority of published studies suggest that nitric oxide plays a damaging role in pulmonary injury resulting from exposure to ozone or asbestos. In contrast, most information supports an anti-inflammatory role of nitric oxide following exposure to lipopolysaccharide. Further investigation is required to elucidate fully the mechanisms involved in determining the role of nitric oxide in the initiation and progression of various pulmonary diseases. [Description provided by NIOSH]
• Subjects:
  Aluminum Silicates Antioxidants Environmental Exposure Lung Diseases Nitrates Occupational Exposure Occupational Health Pathology Respiratory Tract Diseases Safety Silicon Dioxide

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• Keywords:
  Environmental-exposure Lung-disease Lung-disorders Occupational-exposure Oxides Pulmonary-system-disorders Respiratory-system-disorders Silica-dusts Silicates
• ISSN:
  1351-0002
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  7-18
• Volume:
  9
• Issue:
  1
• NIOSHTIC Number:
  nn:20024700
• Citation:
  Redox Rep 2004 Jan; 9(1):7-18
• Contact Point Address:
  Vincent Castranova PhD, Chief, Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, M/S L-2015, 1095 Willowdale Road, Morgantown, West Virginia 26505, USA
• Email:
  vic1@cdc.gov
• CAS Registry Number:
  Nitric oxide (CAS RN 10102-43-9) ; Silica (CAS RN 7631-86-9)
• Federal Fiscal Year:
  2004
• Peer Reviewed:
  True
• Source Full Name:
  Redox Report
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d5137667dda04b7da7e7911b95a7c63fd7619ca479b8456409043513838d5dfebc330404e5202961dcbf481b9d345f28339049678e56f5f7a7995c1ac69c6b89
• Download URL:
  https://stacks.cdc.gov/view/cdc/196361/cdc_196361_DS1.pdf
• File Type:
  [PDF - 309.91 KB ]