Uniformity Test of Bias When the Reference Value Contains Experiment Error

Details

• Personal Author:
  Bartley D ; Kennedy E ; Song R
• Description:
  The uniformity test of biases for analytical methods must address uncertainties in the reference method. If the uncertainty associated with the estimates of true values is significant but ignored in the test of bias equality, the type I error can exceed the prespecified error rate. In general, when biases at each concentration level are confounded with a random component (confounding bias), the usual test of bias equality tests the uniformity of the combined bias, rather than the uniformity of fixed bias-the bias without the random component. Based on a confounding model that takes both the fixed and the confounding biases into account, the actual type I error rate of the uniformity test can be calculated. To eliminate the impact of confounding bias on the uniformity test of fixed biases, a new F'-test is proposed. The new F'-test is simply adding a correction factor to the conventional F-test. The correction factor is directly related to the uncertainty associated with the estimates of true values. A simulation study is conducted to show that the proposed test can bring the type I error rate down to the prespecified level. Data from two aldehyde methods are used to demonstrate how the proposed F'-test works. Recommendations on optimal sample allocation are also provided. [Description provided by NIOSH]
• Subjects:
  Aldehydes Environment Formaldehyde Occupational Health Safety
• Keywords:
  Analytical Methods Data Processing Environmental Factors Sampling
• ISSN:
  0003-2700
• Publisher:
  American Chemical Society
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  310-314
• Volume:
  73
• Issue:
  2
• NIOSHTIC Number:
  nn:20021241
• Citation:
  Anal Chem 2001 Jan; 73(2):310-314
• Email:
  RSong@cdc.gov
• Federal Fiscal Year:
  2001
• NORA Priority Area:
  Research Tools and Approaches ; Other Occupational Concerns
• Peer Reviewed:
  True
• Source Full Name:
  Analytical Chemistry
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:567ac28c646a212ec1a20b1888485c3d3f19652f78d0c4c44ae4ff32f2196eb891fa2f7985cc6eb9f63ae506f5337cd17bdee2ebffe2782eb533d7010fba9820
• Download URL:
  https://stacks.cdc.gov/view/cdc/198655/cdc_198655_DS1.pdf
• File Type:
  [PDF - 48.84 KB ]