Apolipoprotein A-1 Predicts Coronary Heart Disease Only at Low Concentrations of High-Density Lipoprotein Cholesterol: An Epidemiological Study of Japanese-Americans

Details

• Personal Author:
  Burchfiel CM ; Marcovina SM ; Rodriguez BL ; Sharp DS ; Sharrett AR ; Sorlie PD
• Description:
  Conventional epidemiological and clinical studies of apolipoprotein A-1 and high-density lipoprotein-cholesterol have demonstrated, when examined jointly, that high-density lipoprotein is a better predictor of coronary heart disease. This strategy does not take into account known lipid metabolic relationships. A statistical approach that takes into account apolipoprotein A-1 being a constituent of the high-density lipoprotein particle is more appropriate. Among 1,177 Japanese-American men of the Honolulu Heart Program cohort free of disease at baseline (1980-1982), 182 new coronary heart disease cases developed over a 12-year follow-up period. After removing the linear relationship with high-density lipoprotein-cholesterol, a relative measure of apoliprotein A-1 concentration was derived. Based on joint conditions of "low" and "high" relative apoliprotein A-1 concentration and < or =40 and >40 mg/dl for the high-density lipoprotein-cholesterol distribution, four groupings were created. Among relative joint groupings of high/< or =40, low/< or =40, high/>40, and low/>40, respectively, the 12-year coronary heart disease incidence varied from 28.6, 18.2, 8.3, to 11.7 cases per 1,000 person-years. A test of statistical interaction was significant (P=0.028). Additional analyses revealed coronary heart disease cases were more likely among men with triglycerides > 190 mg/dl. Observed patterns of relationships among relative apoliprotein A-1 level, high-density lipoprotein cholesterol, and triglycerides with incident coronary heart disease are consistent with patterns noted in clinical, laboratory, and transgenic animal research more capable of elucidating mechanisms of disease causation. This epidemiological study suggests similar mechanisms may be operating at a population level, and may contribute to the public health burden of coronary heart disease. [Description provided by NIOSH]
• Subjects:
  Cardiovascular System Demography Epidemiology Occupational Health Race Factors Safety
• Keywords:
  Author Keywords: Apolipoprotein A- I Clinical Tests Coronary Arteriosclerosis Demographic Characteristics Heart Heart Rate High-density Lipoprotein-cholesterol Proteins Protein Synthesis Racial Factors Triglycerides

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• ISSN:
  0940-5437
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Hawaii ; Maryland ; OSHA Region 3 ; OSHA Region 9 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  39-48
• Volume:
  30
• Issue:
  1
• NIOSHTIC Number:
  nn:20020805
• Citation:
  Int J Clin Lab Res 2000 Jun; 30(1):39-48
• Contact Point Address:
  D. Sharp, NIOSH/HELD/BB, 1095 Willowdale Road (MS 4020), Morgantown, WV 26505, USA
• Federal Fiscal Year:
  2000
• Peer Reviewed:
  False
• Source Full Name:
  International Journal of Clinical and Laboratory Research
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:74c5578c29354a9d5d5d6c5fd649193ae700ab3e10b025129b8df7af80597b210ff1dc090824e0f9edb7fabca4af0e595a9fc82e5e3bc4e674d82b8188e5b352
• Download URL:
  https://stacks.cdc.gov/view/cdc/198470/cdc_198470_DS1.pdf
• File Type:
  [PDF - 5.49 MB ]