Maternal Lipids in Pregnancy and Later Life Dyslipidemia: The POUCHmoms longitudinal cohort study

Details

• Alternative Title:
  BJOG
• Personal Author:
  Dunietz, Galit Levi ; Holzman, Claudia ; Lyu, Xiru ; Tauman, Riva ; Catov, Janet M.
• Description:
  Objective
  
  Maternal lipid levels increase in normal pregnancies. Here we examine whether pregnancies with the highest total cholesterol, Low-density lipoprotein (LDL) or triglyceride levels, or the lowest High-density lipoprotein (HDL) levels predict future dyslipidemia post-pregnancy.
  
  Design
  
  Longitudinal cohort study
  
  Setting
  
  Five communities in Michigan, USA
  
  Sample
  
  Pregnant women (n=649) with blood lipid levels measured at mid-pregnancy in the Pregnancy Outcomes and Community Health (POUCH) Study and at the POUCHmoms Study follow-up, 7–15y later.
  
  Methods
  
  Maternal mid-pregnancy lipid levels were defined as ‘high’ (upper quartile of triglycerides≥216 mg/dL, LDL≥145 mg/dL, total cholesterol≥256 mg/dL) or ‘low’ (lower quartile, HDL<58mg/dL) using whole sample lipid distributions. At follow-up, dyslipidemia was classified by clinical cutoffs of triglycerides and total cholesterol≥200 mg/dL, LDL≥130 mg/dL and HDL<50 mg/dL. Weighted regression models estimated risk of dyslipidemia at follow-up in relation to pregnancy lipid levels, adjusted for baseline confounders.
  
  Main Outcome Measure
  
  Dyslipidemia later in life.
  
  Results
  
  Mid-pregnancy triglycerides, LDL, and total cholesterol levels at the upper quartile were associated with at least 3-fold increase in risk of abnormal triglycerides, LDL, and total cholesterol levels later in life. Women with low mid-pregnancy HDL levels had just over a twofold increased risk of abnormally low HDL levels at follow-up. These associations persisted following adjustment for covariates, i.e. demographics, lifestyle, and years of follow-up.
  
  Conclusion
  
  Higher mid-pregnancy LDL, total cholesterol and triglycerides, and lower levels of HDL may signal future dyslipidemia risk and the need for closer lipid monitoring to ensure timely interventions that can attenuate cardiovascular disease risk.
  
  
• Subjects:
  Adult Cholesterol Cholesterol, LDL Dyslipidemias Female Humans Lipids Longitudinal Studies Michigan Pregnancy Pregnancy Complications Pregnancy Outcome Risk Factors Triglycerides

  More +
• Keywords:
  High-density Lipoprotein Cholesterol Lipids Low-density Lipoprotein Cholesterol Pregnancy Total Cholesterol Triglycerides
• Source:
  BJOG. 132(2):212-219
• Pubmed ID:
  39377111
• Pubmed Central ID:
  PMC11625654
• Document Type:
  Journal Article
• Funding:
  R01-HD34543/Thrasher Research Fund/ ; 20FY01-38/March of Dimes Foundation/ ; R01 HD034543/HD/NICHD NIH HHSUnited States/ ; R01-HL103825/HL/NHLBI NIH HHSUnited States/ ; U01-DP000143-01/CC/CDC HHSUnited States/ ; 20FY04-37/March of Dimes Foundation/ ; K01 HL144914/HL/NHLBI NIH HHSUnited States/ ; Eunice Kennedy Shriver National Institute of Child Health and Human Development/ ; U01 DP000143/DP/NCCDPHP CDC HHSUnited States/ ; 02816-7/NR/NINR NIH HHSUnited States/
• Volume:
  132
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:8aa09445cca473534845d8910528425e8c77cf3ca260d80ba1aa06e6986d9b0ea745e0887b6ded1d99e92d39345836a94f8afc6e516e0ff4fe9d2d121d702fc7
• File Type: