Expression of Fos-Related Antigen-2 in Rat Hippocampus After Middle Cerebral Arterial Occlusion

Details

• Personal Author:
  Eidizadeh S ; Kassed CA ; O'Callaghan JP ; Pennypacker KR ; Sanberg PR ; Willing AE
• Description:
  AP-1 transcription factors have been shown to be induced in the brain after ischemic injury. However, their roles in neuronal survival or death have yet to be defined. Here, we report the discovery of elevated nuclear levels of fos-related antigen-2 (FRA-2) in the nuclei of hippocampal neurons seven days after middle cerebral artery occlusion (MCAO). Expression of FRA-2 and AP-1 DNA binding activity is elevated in hippocampi ipsilateral as well as contralateral to MCAO. Using Fluoro-Jade staining as a marker of neurodegeneration, FRA-2 was not found to be expressed in degenerating neurons. Thus, FRA-2 is expressed in neurons that survive ischemic insult suggesting a role for this transcription factor in neuronal adaptation to the post-injury state. [Description provided by NIOSH]
• Subjects:
  Animals Antigens Laboratories Occupational Health Safety
• Keywords:
  Animal Studies Brain Damage Brain Disorders Central Nervous System Central Nervous System Disorders Fluoro-Jade Injuries Ischemia Laboratory Animals Neuronal Survival Oke Transcription Factor

  More +
• ISSN:
  0304-3940
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Florida ; OSHA Region 3 ; OSHA Region 4 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-4
• Volume:
  289
• Issue:
  1
• NIOSHTIC Number:
  nn:20020776
• Citation:
  Neurosci Lett 2000 Jul; 289(1):1-4
• Contact Point Address:
  Department of Pharmacology and Therapeutics, College of Medicine, University of South Florida, 12901 Bruce B. Downs Boulevard, MDC 9, Tampa, FL 33612, USA
• Email:
  kpennypa@hsc.usf.edu
• Federal Fiscal Year:
  2000
• Peer Reviewed:
  True
• Source Full Name:
  Neuroscience Letters
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:cc3a6e1536260dd9df0f34dbf17a227437e2a7696e501b61b428b7dacf330ab2bac088944dda5bb7b11b2ce6d3f9e5e2be98a3cb9826987c3b30502462366ecd
• Download URL:
  https://stacks.cdc.gov/view/cdc/198442/cdc_198442_DS1.pdf
• File Type:
  [PDF - 305.01 KB ]