Chronic Dopaminergic Signaling in the Basal Ganglia: A Damage Perspective on Kinases and Fos-Related Antigens

Details

• Personal Author:
  Miller DB ; O'Callaghan JP ; Pennypacker KR
• Description:
  Specific protein phosphorylation pathways have been shown to play a role in cellular adaptation responses underlying addiction to psychostimulants such as methamphetamine and cocaine. Transcriptional regulation through fos-related antigens constitutes one element through which these dopaminergic agonists exert their persistent actions. In addition to their addictive properties, amphetamines are known to damage dopaminergic nerve terminals. Although not widely appreciated, protein phosphorylation cascades and fos-related antigens also may play a role in the neurotoxic actions of substituted amphetamines such as methamphetamine. Here we document the involvement of the dopaminoceptive phosphoprotein, DARPP-32, the fos-related antigen, FRA-2, and the growth associated protein kinase, MAP kinase, in the neurotoxic action of known dopaminergic neurotoxicants, including methamphetamine. The addictive and neurotoxic properties of psychostimulants may share some molecular signaling mechanisms. [Description provided by NIOSH]
• Subjects:
  Antigens Nervous System Occupational Health Safety Substance-Related Disorders
• Keywords:
  Drug Abuse Drugs Nerve Damage Neurotoxic Effects Neurotoxicity Neurotoxicology Neurotoxins Proteins
• ISSN:
  1355-6215
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Florida ; OSHA Region 3 ; OSHA Region 4 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  369-376
• Volume:
  5
• Issue:
  3
• NIOSHTIC Number:
  nn:20020767
• Citation:
  Addiction Biol 2000 Jul-Sep; 5(3):369-376
• Contact Point Address:
  James P. O'Callaghan PhD, Centers for Disease Control and Prevention, NIOSH/HELD/TMBB (MS-3014), 1095 Willowdale Road, Morgantown, WV 26505-2888, USA
• Email:
  jdo5@cdc.gov
• Federal Fiscal Year:
  2000
• Peer Reviewed:
  True
• Source Full Name:
  Addiction Biology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8f8e96b58c38aa9bfb3e302d486e7eefc7b62d2fa639083083d145c6b7fa4dbcaada681fc6ebf0c400c3ab94c2dde568ec7aa8ef6fb3cac850a5701ae93c34e9
• Download URL:
  https://stacks.cdc.gov/view/cdc/198435/cdc_198435_DS1.pdf
• File Type:
  [PDF - 691.48 KB ]