Phenobarbital and Dizocilpine Can Block Methamphetamine-Induced Neurotoxicity in Mice by Mechanisms That Are Independent of Thermoregulation

Details

• Personal Author:
  Bowyer JF ; Holson RR ; Miller DB ; O'Callaghan JP
• Description:
  Body temperature profiles observed during methamphetamine (METH) exposure are known to affect dopamine and tyrosine hydroxylase (TH) levels in the striatum of mice; hyperthermia potentiates depletion while hypothermia is protective against depletions. In the current study, the doses of METH were sufficiently great that significant dopamine and TH depletions occurred even though hypothermia occurred. Four doses, administered at 2 h intervals, of 15 mg/kg (4x15 mg/kg) D-METH significantly decreased TH and dopamine levels to 50% of control in mice becoming hypothermic during dosing in a 13 degrees C environment. Phenobarbital or dizocilpine during METH exposure blocked the depletions while diazepam did not. Phenobarbital and dizocilpine did not block depletions by altering the hypothermic profiles from that observed during METH only exposure. Here we show that phenobarbital and dizocilpine can block measures of METH neurotoxicity by non-thermoregulatory mechanisms. [Description provided by NIOSH]
• Subjects:
  Animals Hypothermia Laboratories Nervous System Occupational Health Safety Substance-Related Disorders
• Keywords:
  Animal-studies Author Keywords: Methamphetamine Dopamine Drug-abuse Drugs Laboratory-animals Neurotoxic-effects Neurotoxicity Neurotoxicology Striatum Thermoregulation

  More +
• ISSN:
  0006-8993
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Arkansas ; New Mexico ; OSHA Region 3 ; OSHA Region 6 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  179-183
• Volume:
  919
• Issue:
  1
• NIOSHTIC Number:
  nn:20021680
• Citation:
  Brain Res 2001 Nov; 919(1):179-183
• Contact Point Address:
  Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
• Email:
  jbowyer@nctr.fda.gov
• Federal Fiscal Year:
  2002
• Peer Reviewed:
  True
• Source Full Name:
  Brain Research
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bfe658d7b5c9984e79d23a641fdc44fa12d6b481ba85130a6b72843d31cab612343b20b3f8bc94678c4ad12162b31562140600ff345470c6285e1bd335872084
• Download URL:
  https://stacks.cdc.gov/view/cdc/198807/cdc_198807_DS1.pdf
• File Type:
  [PDF - 192.66 KB ]