Exposure to Hazardous Substances and Male Reproductive Health: A Research Framework

Details

• Personal Author:
  Bar-Chama N ; Chapin RE ; Golden AL ; Landrigan, Philip J. ; Moline JM ; Perreault SD ; Rauch ME ; Schrader, Steven M. ; Smith E ; Suk WA
• Description:
  The discovery in the mid-1970s that occupational exposures to pesticides could diminish or destroy the fertility of workers sparked concern about the effects of hazardous substances on male reproductive health. More recently, there is evidence that sperm quantity and quality may have declined worldwide, that the incidence of testicular cancer has progressively increased in many countries, and that other disorders of the male reproductive tract such as hypospadias and cryptorchidism may have also increased. There is growing concern that occupational factors and environmental chemical exposures, including in utero and childhood exposures to compounds with estrogenic activity, may be correlated with these observed changes in male reproductive health and fertility. We review the evidence and methodologies that have contributed to our current understanding of environmental effects on male reproductive health and fertility and discuss the methodologic issues which confront investigators in this area. One of the greatest challenges confronting researchers in this area is assessing and comparing results from existing studies. We elaborate recommendations for future research. Researchers in the field of male reproductive health should continue working to prioritize hazardous substances; elucidate the magnitude of male reproductive health effects, particularly in the areas of testicular cancer, hypospadias, and cryptorchidism; develop biomarkers of exposure to reproductive toxins and of reproductive health effects for research and clinical use; foster collaborative interdisciplinary research; and recognize the importance of standardized laboratory methods and sample archiving [Description provided by NIOSH]
• Subjects:
  Demography Environmental Exposure Hazardous Substances Insecticides Neoplasms Occupational Exposure Occupational Health Safety Sex Characteristics Urogenital Diseases Urogenital System

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• Keywords:
  Author Keywords: Hazardous Substances Cancer Demographic Characteristics Environmental Exposure Fertility Health Hazards In Utero Studies Male Reproductive Health Occupational Exposure Occupational Health Pesticides Reproductive Effects Reproductive System Disorders Research Semen Quality Sex Factors Worker Health Workers

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• ISSN:
  0091-6765
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  New York ; North Carolina ; Ohio ; OSHA Region 2 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 6 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  108
• Issue:
  9
• NIOSHTIC Number:
  nn:20020758
• Citation:
  Environ Health Perspect 2000 Sep; 108(9):803-813
• Contact Point Address:
  J. Moline, Mount Sinai School of Medicine, Box 1057, 1 Gustave Levy Place, New York, NY 10029 USA
• Email:
  jacqueline.moline@mssm.edu
• Federal Fiscal Year:
  2000
• Peer Reviewed:
  True
• Source Full Name:
  Environmental Health Perspectives
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:fbdd0f739f524fd65c7494eaf273c6210107a945884345a6c165356001fadc9ac034648d09ae99a3652428f0ee255bb105a8e0bc27f54a1a539f8872d90725c4
• Download URL:
  https://stacks.cdc.gov/view/cdc/198427/cdc_198427_DS1.pdf
• File Type:
  [PDF - 120.67 KB ]