The Role of Tumor Necrosis Factor Alpha in Chemical-Induced Hepatotoxicity

Blazka ME; Bruccoleri A; Gallucci RM; Luster MI; Matheson JM; Simeonova PP; Yucesoy, Berran

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The Role of Tumor Necrosis Factor Alpha in Chemical-Induced Hepatotoxicity

Public Domain

2000/09/01
By Blazka ME ; Bruccoleri A ; Gallucci RM ; ...

Details

Personal Author:

Blazka ME ; Bruccoleri A ; Gallucci RM ; Luster MI ; Matheson JM ; Simeonova PP ; Yucesoy, Berran
Description:

Only recently have toxicologists come to understand the role of inflammation, and TNFalpha specifically, in classical toxicological processes. This relationship appears fairly complex, as inflammation and proliferation may well be only one facet of a time- and dose-dependent continuum of toxicological and repair processes. Not surprisingly, considerable efforts are being undertaken using our newly found understanding of molecular control to develop specific and safe chemical, biological, and molecular regulators of TNFalpha for potential therapeutic use. Their effectiveness in controlling environmental or occupational diseases has yet to be established. [Description provided by NIOSH]
Subjects:

Environmental Exposure Environmental Pollution Liver Occupational Diseases Occupational Health Safety Toxicology
Keywords:

Environmental Hazards Environmental Health Hepatocytes Hepatotoxicity Hepatotoxins Occupational Diseases
ISBN:

9781573312653
ISSN:

0077-8923
Document Type:

Text
Genre:

Journal Article
Place as Subject:

New Jersey ; OSHA Region 2 ; OSHA Region 3 ; West Virginia
CIO:

National Institute for Occupational Safety and Health (NIOSH)
Division:

HELD - Health Effects Laboratory Division
Topic:

Workplace Safety & Health
Location:

North America
Pages in Document:

214-220
Volume:

919
NIOSHTIC Number:

nn:20020738
Citation:

Ann NY Acad Sci 2000 Sep; 919:214-220
Email:

myl6@cdc.gov
Federal Fiscal Year:

2000
Peer Reviewed:

True
Source Full Name:

Annals of the New York Academy of Sciences
Collection(s):

National Institute for Occupational Safety and Health
Main Document Checksum:

urn:sha-512:992c2ca1b146e25fd728679fe0b5588f26dab21959723e4c481d7ca692db2a19f55481d5750b4f55b234180a72ce4e8648c8cbf65fada5c0428b6f3fc249b373
Download URL:

https://stacks.cdc.gov/view/cdc/198409/cdc_198409_DS1.pdf
File Type:

[PDF - 2.87 MB ]

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