Acute Response of Rats to Intratracheal Instillation of Airborne Dust Collected at a Nylon Flocking Plant

Details

• Personal Author:
  Battelli L ; Burkhart, Joseph E. ; Castranova, Vincent ; Goldsmith T ; Hubbs A ; Jones, William G. ; Mercer RR ; Piacitelli, Chris A. ; Porter Dale ; Robinson VA ; Scabilloni J ; Schwegler-Berry D ; Washko, Rita ; Whitmer M
• Description:
  Recently several cases of lymphocytic bronchiolitis have been identified in workers at a nylon flocking plant. The objective of this investigation was to characterize the acute pulmonary reaction to exposure to airborne thoracic/respirable dust collected from this factory and to identify a component of the dust which may cause interstitial lung disease. Rats were intratracheally instilled with 2.56 mg of dust and pulmonary reactions monitored 1 day post-exposure. The acute reactions included: increased breathing rate, PMN infiltration, activation of macrophages, and an elevation of the albumin levels of the lavage fluid. These acute reactions dissipated at 29 days post-exposure. They were not associated with endotoxin or other water extractable components but were related to nylon shreds which were small enough to reach the alveolar region of the lung. The data indicate that nylon shreds can be generated during cutting of large nylon fibers and that this material can enter the lungs and result in inflammation and possible disease. [Description provided by NIOSH]
• Subjects:
  Dust Occupational Health Particulate Matter Respiratory Tract Diseases Safety
• Keywords:
  Fibrous-bodies Fibrous-dusts Occupational-health Pulmonary-system-disorders Synthetic-fibers
• ISSN:
  1059-2644
• Publisher:
  National Cotton Council, PO Box 12285, Memphis, TN 38182
• Document Type:
  Text
• Genre:
  Proceedings
• Place as Subject:
  Florida ; OSHA Region 3 ; OSHA Region 4 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  164-166
• Volume:
  1
• NIOSHTIC Number:
  nn:20000919
• Citation:
  1999 Proceedings Beltwide Cotton Conferences, January 3 - 7, Orlando, FL. Memphis, TN: National Cotton Council of America, 1999 Jan; 1:164-166
• Editor(s):
  Dugger P; Richter D
• Federal Fiscal Year:
  1999
• Peer Reviewed:
  False
• Source Full Name:
  1999 Proceedings Beltwide Cotton Conferences, January 3 - 7, Orlando, FL
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:feeacc7c633a881f7ce242923d91a78a69d9eb521a979848c3b4978f24a3cdaa11fc75eb340c950e1c01c79919e1ed8b084b88b375c6d0735fc705de15847c4a
• Download URL:
  https://stacks.cdc.gov/view/cdc/198262/cdc_198262_DS1.pdf
• File Type:
  [PDF - 37.81 KB ]