Testing of Fibrous Particles: Short-Term Assays and Strategies – Report of an ILSI Risk Science Institute Working Group

Details

• Personal Author:
  Bernstein D ; Castranova, Vincent ; Donaldson K ; Fubini B ; Hadley J ; Hesterberg T ; Kane A ; Lai D ; McConnell EE ; Muhle H ; Oberdorster G ; Olin S ; Warheit DB
• Description:
  Natural and synthetic fibrous materials are widely used in construction, industrial applications, and biomedical devices, as well as in consumer products. Fibrous materials are chemically and structurally diverse; however, for regulatory purposes, fibers are defined on the basis of their size and shape. Widely varied natural and synthetic fibers are currently in commercial use or under development, suggesting the need to understand the potential for adverse health effects if respirable fibers were released during production or application. In contrast to asbestos or synthetic vitreous fibers, other types of fibers have not been systematically assessed for carcinogenicity using lifetime rodent inhalation assays because these tests are technically demanding, expensive, and require large numbers of animals. [Description provided by NIOSH]
• Subjects:
  Dust Occupational Health Particulate Matter Safety
• Keywords:
  Fibrous-bodies Fibrous-dusts Occupational-health Respirable-dust Synthetic-fibers Synthetic-materials
• ISSN:
  0895-8378
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Delaware ; District of Columbia ; Illinois ; New York ; North Carolina ; Ohio ; OSHA Region 1 ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; Rhode Island ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  497-537
• Volume:
  17
• Issue:
  10
• NIOSHTIC Number:
  nn:20028023
• Citation:
  Inhal Toxicol 2005 Sep; 17(10):497-537
• Federal Fiscal Year:
  2005
• Peer Reviewed:
  True
• Source Full Name:
  Inhalation Toxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:07c89df9533a77ec93988285580f3785529d0242a095e903e7a25212f0e78f3ab7615366e12f5dd2049a43ccb8e588750329cb03930c858d91c19913c426a17d
• Download URL:
  https://stacks.cdc.gov/view/cdc/189733/cdc_189733_DS1.pdf
• File Type:
  [PDF - 967.58 KB ]