Induction of Gene Expression by Environmental Oxidants Associated with Inflammation, Fibrogenesis, and Carcinogenesis

Details

• Personal Author:
  Janssen YM ; Jimenez LA ; Mossman BT ; Timblin CR ; Zanella CL
• Description:
  Induction of gene expression by mineral dusts and other oxidants capable of inducing inflammatory, fibrogenic, and carcinogenic responses was reviewed. The review described the characteristics of genes that play important roles in cell proliferation and discussed stress response genes, genes important in inducing inflammatory responses, cellular defense mechanisms against environmental agents that induce oxidative stress, gene expression involved in apoptosis, and considered signal transduction pathways involved in the induction of inflammatory processes by mineral dusts. A number of experimental studies have shown that mineral dusts such as asbestos (1332214) and crystalline silica (14808607) induce oxidative stress through inflammatory processes involving the cooperative action of various cytokines and chemokines. Signals generated extracellularly at the cell surface by these agents or by oxidants acting as second messengers can proceed along various pathways to induce a change in the phosphorylation status of transcription factors. This may then activate or inactivate transcription factors that will induce changes in gene expression that will culminate in endpoints such as apoptosis, fibrogenesis, or carcinogenesis. A nuclear transcription factor kappa B (NF-kappaB) dependent pathway appears to be the major mechanism underlying the inflammatory response that is observed in asbestos and crystalline silica induced pulmonary disease. NF-kappaB is a transcription factor involved in activation of genes that are involved in cell proliferation and inflammation. Many genes have NF- kappaB sites in their promoter regions that can be involved in gene expression. [Description provided by NIOSH]
• Subjects:
  Cell Division Dust Genetics Neoplasms Occupational Health Respiratory Tract Diseases Safety
• Keywords:
  Cancer Cell-division Cell-function Fibrogenicity Mineral-dusts NIOSH-Grant Oxidative-processes Physiological-stress Pulmonary-system-disorders Respiratory-system-disorders
• ISSN:
  041207681
• Publisher:
  Chapman and Hall
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Book
• Place as Subject:
  New York ; OSHA Region 1 ; OSHA Region 2 ; Vermont
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  387-414
• NIOSHTIC Number:
  nn:00241818
• Citation:
  Oxidative Stress and Signal Transduction 1996; :387-414
• Contact Point Address:
  Pathology University of Vermont Medical Alumni Bldg Burlington, VT 05405
• CAS Registry Number:
  Asbestos (CAS RN 1332-21-4) ; Quartz (SiO2) (CAS RN 14808-60-7)
• Editor(s):
  Cadenas E; Forman HJ
• Federal Fiscal Year:
  1996
• NORA Priority Area:
  Pulmonary System Disorders
• Performing Organization:
  University of Vermont & St Agric College, Burlington, Vermont
• Peer Reviewed:
  False
• Start Date:
  19940930
• Source Full Name:
  Oxidative Stress and Signal Transduction
• End Date:
  19970929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a236575a50a834399d36c190fa1cc86748a7bc2bd29c776982664196dd9f0e4ac8da6d81d5efd8925728e130f85f57ebe75f01bab2d96a9520b6c5225f287df9
• Download URL:
  https://stacks.cdc.gov/view/cdc/198118/cdc_198118_DS1.pdf
• File Type:
  [PDF - 620.50 KB ]