Mitogenic response to Micropolyspora faeni cell walls.

Details

• Personal Author:
  Buyrrell R ; Smith SM ; Snyder IS
• Description:
  The mitogenic response of splenic lymphocytes from unsensitized guinea pigs to cell wall fractions prepared from Micropolyspora faeni (M-faeni) was investigated. Three M-faeni cell wall fractions were incubated with lymphocyte preparations for 48 hours. All of the fractions were mitogenic for the lymphocytes, and the response was dose dependent. The most active cell wall fractions were primarily B cell mitogens. The heat stable mitogenic reactivity was associated with polypeptide and polysaccharide. The mitogenic potential of the reactive material decreased after lysozyme digestion, indicating that part of the material was peptidoglycan. The authors suggest that mitogenic reactivity is host related. [Description provided by NIOSH]
• Subjects:
  Cell Division Dust Occupational Health Respiratory Tract Diseases Safety
• Keywords:
  Biological-responses Cell-division Cellular-reactions Dose-response Extrinsic-allergic-alveolitis Farmers-lung NIOSH-Grant NIOSH-Publication Nuclear-chemistry Organic-dusts Pulmonary-system-disorders Respiratory-system-disorders

  More +
• ISSN:
  0091-6749
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  298-304
• Volume:
  65
• Issue:
  4
• NIOSHTIC Number:
  nn:00094467
• Citation:
  J Allergy Clin Immunol 1980 Apr; 65(4):298-304
• Contact Point Address:
  Microbiology West Virginia University Med C Department of Microbiology Morgantown, W VA 26506
• Federal Fiscal Year:
  1980
• NORA Priority Area:
  Pulmonary System Disorders
• Performing Organization:
  West Virginia University, Morgantown, West Virginia
• Peer Reviewed:
  True
• Start Date:
  19710601
• Source Full Name:
  Journal of Allergy and Clinical Immunology
• End Date:
  19830831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:016dbae0a9adb66fb70372928f37e9def2f807dd3a4f8451135f6f1b0db40abc779aa83379129378edabcfedaf59ceab2fcc20868405dd5181d05396b5acf08d
• Download URL:
  https://stacks.cdc.gov/view/cdc/184339/cdc_184339_DS1.pdf
• File Type:
  [PDF - 838.71 KB ]