Influence of Change in Aerobic Fitness and Weight on Prevalence of Metabolic Syndrome

Details

• Journal Article:
  Preventing Chronic Disease (PCD)
• Personal Author:
  Crist, Laura A. ; Champagne, Catherine M. ; Corsino, Leonor ; Lien, Lillian F. ; Zhang, Guangyu ; Young, Deborah Rohm
• Description:
  Introduction
  
  The metabolic syndrome is the clustering of several cardiometabolic risk factors that can lead to the development of coronary heart disease and type 2 diabetes. We evaluated whether a change in aerobic fitness resulting from a lifestyle intervention could significantly change the odds of metabolic syndrome prevalence.
  
  Methods
  
  Participants (n = 810) were recruited into PREMIER, a multicenter, randomized, controlled clinical trial with outcome assessments at 6 and 18 months. The primary eligibility criterion was a diagnosis of prehypertension or stage 1 hypertension. PREMIER randomized participants to 2 lifestyle interventions, both of which included increased physical activity, or an advice-only control group. Participants completed a submaximal treadmill exercise test; we used reduction in heart rate as the measure of improved aerobic fitness. We used logistic regression to determine intervention effects on metabolic syndrome prevalence. Our models controlled for dietary pattern change.
  
  Results
  
  The lifestyle interventions had no significant effect on metabolic syndrome prevalence at 6 months or 18 months. When combining intervention and control groups, at 6 and 18 months, a 1-beat-per-minute reduction in heart rate was associated with a 4% reduction in prevalence of metabolic syndrome (P < .001). When we tested for weight change as a mediator, the association was no longer significant.
  
  Conclusion
  
  Increased aerobic fitness may reduce prevalence of metabolic syndrome. This association appears to be mediated through concomitant weight change.
  
  
• Subjects:
  Body Weight Counseling Diet Exercise Exercise Test Exercise Tolerance Female Health Behavior Heart Rate Humans Life Style Male Metabolic Syndrome X Middle Aged Original Research Physical Fitness Prevalence Treatment Outcome Weight Loss

  More +
• Source:
  Prev Chronic Dis. 2012; 9.
• ISSN:
  1545-1151
• Document Type:
  Journal Article
• Volume:
  9
• Collection(s):
  Preventing Chronic Disease
• Main Document Checksum:
  urn:sha-512:99fe1c2720a79df77a1c479b3bbe2f2595ad7ddf42e5e2354a53445ebcd2b77dd34142848b605f93ce65b21799a6aa73603fcec3456e1dcb83d682ce6ee891bc
• Download URL:
  https://stacks.cdc.gov/view/cdc/19809/cdc_19809_DS1.pdf
• File Type:
  [PDF - 208.82 KB ]