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Lifestyle Intervention for People With Severe Obesity and Serious Mental Illness
  • Published Date:
    Sep 16 2015
  • Source:
    Am J Prev Med. 50(2):145-153.
Filetype[PDF-380.40 KB]

  • Pubmed ID:
  • Pubmed Central ID:
  • Description:

    People with serious mental illness experience elevated severe obesity rates, yet limited evidence documents whether lifestyle intervention participation can benefit these individuals. This study examined the impact of the In SHAPE lifestyle intervention on weight loss among participants with serious mental illness and severe obesity (BMI ≥40 kg/m2) compared with participants who are overweight (BMI 25 to <30 kg/m2) and have class I (BMI 30 to <35 kg/m2) or have class II (BMI 35 to <40 kg/m2) obesity.


    Data were combined from three trials of the 12-month In SHAPE intervention for individuals with serious mental illness collected between 2007 and 2013 and analyzed in 2014. In SHAPE includes individual weekly meetings with a fitness trainer, a gym membership, and nutrition education. The primary outcome was weight loss. Secondary outcomes were fitness, blood pressure, lipids, and program adherence.


    Participants (N=192) were diagnosed with schizophrenia spectrum (53.1%) or mood (46.9%) disorders. At 12 months, the overall sample showed significant weight loss, but differences among BMI groups were not significant (severe obesity, 2.57% [7.98%]; class II, 2.26% [8.69%]; class I, 1.05% [6.86%]; overweight, 0.83% [7.62%]). One third of participants with severe obesity achieved ≥5% weight loss, which was comparable across groups. More participants with severe obesity achieved ≥10% weight loss (20%) than overweight (2.9%, p=0.001) and class I (5.9%, p<0.001), but not class II (17.8%, p=0.974), obesity groups.


    People with severe obesity and serious mental illness benefit similarly to those in lower BMI groups from lifestyle intervention participation.

  • Document Type:
  • Collection(s):
  • Funding:
    R01 MH078052/MH/NIMH NIH HHS/United States
    U48DP005018/DP/NCCDPHP CDC HHS/United States
    R01 MH089811-01/MH/NIMH NIH HHS/United States
    U48DP001935-0/DP/NCCDPHP CDC HHS/United States
    R01 MH089811/MH/NIMH NIH HHS/United States
    U48 DP005018/DP/NCCDPHP CDC HHS/United States
    U48 DP001935/DP/NCCDPHP CDC HHS/United States
    R01 DD000140/DD/NCBDD CDC HHS/United States
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