Reduction of chromium(VI) and Its Relationship to Carcinogenesis

Details

• Personal Author:
  Casranova V ; Chen CT ; Chiu A ; Halliwell B ; Shi X ; Vallyathan V
• Description:
  Although Cr(VI)-containing compounds are well-documented carcinogens, their mechanism of action is still not well understood. Recent studies have suggested that reduction of Cr(VI) to its lower oxidation states and related free-radical reactions play an important role in carcinogenesis. This article summarizes recent studies on (1) the reduction of Cr(VI) by ascorbate, diol- and thiol-containing molecules, certain flavoenzymes, cell organelles, intact cells, and whole animals; (2) free-radical production with emphasis on hydroxy radical generation via Fenton or Haber-Weiss type reactions; and (3) freeradical-induced cellular damage, such as DNA strand breaks, hydroxylation of 2'deoxyguanosine, and activation of nuclear transcription factor B. [Description provided by NIOSH]
• Subjects:
  Carcinogens Cells, Cultured Chromium Dust Environmental Exposure Environmental Pollution Free Radicals Metals Metals, Heavy Occupational Health Poisoning Safety

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• Keywords:
  Carcinogenesis Cell-biology Cell-cultures Cell-damage Cellular-reactions Chrome-plating Chromium-compounds Environmental-contamination Environmental-exposure Environmental-hazards Free-radical-generation Free-radicals Heavy-metal-poisoning Heavy-metals In-vivo-study Metal-compounds Metal-dusts Metal-poisoning Oxidation Oxidation-reduction-reactions Statistical-analysis

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• ISSN:
  1093-7404
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  District of Columbia ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  87-104
• Volume:
  2
• Issue:
  1
• NIOSHTIC Number:
  nn:20027790
• Citation:
  J Toxicol Environ Health B 1999 Jan/Mar; 2(1):87-104
• Contact Point Address:
  Xianglin Shi, PhD, Pathology and Physiology Research Branch, HELD, NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA
• Email:
  xas0@cdc.gov
• CAS Registry Number:
  Chromic trioxide (CAS RN 1333-82-0) ; Chromium (CAS RN 7440-47-3) ; Chromium(6+) (CAS RN 18540-29-9)
• Federal Fiscal Year:
  1999
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Toxicology and Environmental Health, Part B: Critical Reviews
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b747dcb3dfdbfbb35f072a3407bc2d2e89eb5d3aa8b370db72cdb124bc683da1d6f79a38b40657de9d1f2dd5e6eac72f74a52d1c20d78e0555045cf1dc30b45a
• Download URL:
  https://stacks.cdc.gov/view/cdc/197660/cdc_197660_DS1.pdf
• File Type:
  [PDF - 254.13 KB ]