Positional Isomers of Acetaminophen Differentially Induce Proliferation of Cultured Breast Cancer Cells

Details

• Personal Author:
  Harnagea-Theophilus E ; Miller MR ; Rao N
• Description:
  This study demonstrates that acetaminophen (p-acetamidophenol) stimulates proliferation of estrogen-responsive cultured breast cancer cells and assesses if the proliferative activity of p-acetamidophenol is influenced by the IOH moiety position on the benzene ring. The effects of p-, m-, and o-acetamidophenol on cell number and on percentage cells in S phase of the cell cycle were determined for two estrogen receptor positive, human breast cancer cell lines, T47D and MCF7. Therapeutic concentrations of p-acetamidophenol (0.1 mM) significantly increased breast cancer cell proliferation. The relative order of potency of isomers in stimulating proliferation in both cell types was p->m->o-acetamidophenol, indicating the IOH position on the benzene ring influences the proliferation output in cultured breast cancer cells. [Description provided by NIOSH]
• Subjects:
  Benzene Cells, Cultured Neoplasms Occupational Health Safety
• Keywords:
  Benzenes Breast-cancer Cancer Cell-cultures Cell-function
• ISSN:
  0378-4274
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  11-18
• Volume:
  104
• Issue:
  1
• NIOSHTIC Number:
  nn:20027684
• Citation:
  Toxicol Lett 1999 Jan; 104(1):11-18
• Contact Point Address:
  Eugenia Harnagea-Theophilus, Department of Pharmacology and Toxicology, West Virginia University, P.O. Box 9142, R.C. Byrd Health Sciences Center, Morgantown, WV 26506-9142
• Email:
  mmiller3@wvu.edu
• Federal Fiscal Year:
  1999
• Peer Reviewed:
  True
• Source Full Name:
  Toxicology Letters
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:596c7b5881464ee64a2037c5ab9d551bc0ce57f63d7e2e28551efca9f6ff4b497808f001b3e4ba7b2e07c301416123984df06426aeef0e2991ff609d252f59ff
• Download URL:
  https://stacks.cdc.gov/view/cdc/197625/cdc_197625_DS1.pdf
• File Type:
  [PDF - 131.76 KB ]