2,4-Dichlorophenoxyacetic Acid Residues in Semen of Ontario Farmers

Details

• Personal Author:
  Arbuckle TE ; Bancej CM ; Claman P ; Cole D ; Hall JC ; Schrader, Steven M. ; Turner LA
• Description:
  Although paternal exposures to environmental toxicants probably play a role in adverse pregnancy outcomes, few data are available on the extent of this exposure. One semen and two 24-h urine samples were collected from 97 Ontario farmers who had recently used the phenoxy herbicides 2,4-D (2,4-dichlorophenoxyacetic acid) and/or MCPA ([4-chloro-2-methylphenoxy] acetic acid). Both samples were analyzed for 2,4-D using an immunoassay-based technique. Approximately 50% of the semen samples had detectable levels of 2,4-D (=5.0 ppb (ng/mL)). Semen levels of 2,4-D were correlated more closely with the second of the two urine samples. Although several studies have measured 2,4-D in the urine of applicators, this study is the first to attempt to measure 2,4-D levels in semen. As these pesticides can be excreted in the semen, they could be toxic to sperm cells and be transported to the woman and developing embryo/fetus. Further research is needed to understand how pesticide handling practices can affect semen pesticide residues and the relationship between the levels observed and reproductive health. [Description provided by NIOSH]
• Subjects:
  Agriculture Environmental Monitoring Family Herbicides Occupational Health Safety Urine Urogenital Diseases Urogenital System
• Keywords:
  Agricultural-chemicals Agricultural-industry Agricultural-workers Biological-effects Biological-monitoring Exposure-assessment Families Reproductive-system Reproductive-system-disorders Urinalysis Urogenital-system Urogenital-system-disorders

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• ISSN:
  0890-6238
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  421-429
• Volume:
  13
• Issue:
  6
• NIOSHTIC Number:
  nn:20027404
• Citation:
  Reprod Toxicol 1999 Nov; 13(6):421-429
• CAS Registry Number:
  (2,4-Dichlorophenoxy)acetic acid (CAS RN 94-75-7)
• Federal Fiscal Year:
  2000
• Peer Reviewed:
  True
• Source Full Name:
  Reproductive Toxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:352e84f301a120fa8172db49c53070ac2d08a713a70119ac51834f6b5989144abb73534d6801758ede597ac7845651ffec51f2f0830edbfee1384565ffde42da
• Download URL:
  https://stacks.cdc.gov/view/cdc/197565/cdc_197565_DS1.pdf
• File Type:
  [PDF - 76.37 KB ]