Addressing Uncertainty in Epidemiologically Based Risk Assessment

Details

• Personal Author:
  Stayner, Leslie T. ; Stram D ; Vrijheid M
• Description:
  The use of epidemiologic data for quantitative risk assessments (QRA) is becoming increasingly common. Part of the reason for this increase is that using human studies avoids the uncertainties associated with extrapolating from animals to humans. However, using epidemiologic data in QRA introduces a whole other set of uncertainties, which are largely related to the observational nature of epidemiologic data. Of particular concern are issues related to inadequate sample size, unresolved confounding or other biases, inadequate length of follow-up, and errors in the ascertainment of exposures. The issue of errors in the estimation of exposures has been of large concern particularly in occupaional studies. We are evalkuating methods for estimating confidence intervals that reflect both uncertainties related to random error, and potential errors in exposure using Monte Carlo maximum likelihood methods. These methods will be illustrated using an epidemiological study of nuclear power plant workers. [Description provided by NIOSH]
• Subjects:
  Environmental Monitoring Epidemiology Occupational Health Risk Assessment Risk Factors Safety
• Keywords:
  Exposure-assessment Quantitative-analysis Risk-analysis Risk-factors Statistical-analysis
• Publisher:
  Society for Risk Analysis
• Document Type:
  Text
• Genre:
  Abstract or Summary ; Proceedings
• Place as Subject:
  Maryland ; Ohio ; OSHA Region 3 ; OSHA Region 5 ; Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20027207
• Citation:
  Society for Risk Analysis 2003 Annual Meeting. Bridging Risk Divides, Baltimore, Maryland, December 7-10, 2002. McLean, VA: Society for Risk Analysis, 2003 Dec; :108
• Email:
  lstayner@cdc.gov
• Federal Fiscal Year:
  2004
• Peer Reviewed:
  False
• Source Full Name:
  Society for Risk Analysis 2003 Annual Meeting Bridging Risk Divides, Baltimore, Maryland, December 7-10, 2002
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2eea76dae14eaceba7c3dc8ecbf60cf0c8be50d0228731d2d6451d644bf5e1af7bf719e8f833bc713d5b7a5a9cbdaf080f3da0553636496aa094b379faff4189
• Download URL:
  https://stacks.cdc.gov/view/cdc/197505/cdc_197505_DS1.pdf
• File Type:
  [PDF - 405.24 KB ]