DLC-1, a Rho GTPase-Activating Protein with Tumor Suppressor Function, Is Essential for Embryonic Development

Details

• Personal Author:
  Avner MR ; Durkin ME ; Huh CG ; Popescu NC ; Thorgeirsson SS ; Yuan BZ
• Description:
  DLC-1 (deleted in liver cancer 1) is a Rho GTPase-activating protein that is able to inhibit cell growth and suppress tumorigenesis. We have used homologous recombination to inactivate the mouse DLC-1 gene (Arhgap7). Mice heterozygous for the targeted allele were phenotypically normal, but homozygous mutant embryos did not survive beyond 10.5 days post coitum. Histological analysis revealed that DLC-1-/- embryos had defects in the neural tube, brain, heart, and placenta. Cultured fibroblasts from DLC-1-deficient embryos displayed alterations in the organization of actin filaments and focal adhesions. [Description provided by NIOSH]
• Subjects:
  Animals Carcinogens Cardiovascular Diseases Cardiovascular System Histology Laboratories Liver Neoplasms Nervous System Nervous System Disorders Occupational Health Respiratory Tract Diseases Safety Teratogenesis

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• Keywords:
  Animal-studies Author Keywords: Rho GTPase-activating Protein Cardiovascular-system-disorders Cell-growth Central-nervous-system-disorders Embryonic Lethal Knock-out Mouse; Laboratory-animals Liver-cancer Proteins Pulmonary-system-disorders Respiratory-system-disorders Teratology Tumorigenesis Tumorigens Tumors

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• ISSN:
  0014-5793
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  579
• Issue:
  5
• NIOSHTIC Number:
  nn:20026874
• Citation:
  FEBS Lett 2005 Feb; 579(5):1191-1196
• Contact Point Address:
  Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892, USA
• Email:
  marian_durkin@nih.gov
• Federal Fiscal Year:
  2005
• NORA Priority Area:
  Research Tools and Approaches: Cancer Research Methods
• Peer Reviewed:
  False
• Source Full Name:
  Federation of European Biochemical Societies Letters
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:350ef2e94ad5e052a20a903868cd3b85360596e1a08fc8ef4e5d0b70659a75cf8af8f9c90fee9ee5ed3980f47e926531b574bb0311b001f3724164c739a6da57
• Download URL:
  https://stacks.cdc.gov/view/cdc/197401/cdc_197401_DS1.pdf
• File Type:
  [PDF - 511.90 KB ]