Effect of Acute and Chronic Exposure to the Cleanser, Trichloroethylene, on the Dermal Absoprtion of the Biocide Triazine

Details

• Personal Author:
  Barlow BM ; Baynes RE ; Brooks JD ; Riviere JE ; Yeatts JL
• Description:
  Triazine is often added to cutting-fluid formulations in the metal machining industry as a preservative that inhibits the growth of biological material. Unfortunately, triazine has been shown to cause contact dermatitis in exposed workers. Trichloroethylene, TCE, is a solvent used for cleaning and rinsing. The purpose of this study was to examine the effect of TCE on the dermal absorption of the biocide triazine. A porcine skin in vitro flow-through diffusion cell system was used for these studies. In one set of experiments, the diffusion cells were dosed topically with 14C-Triazine mixtures containing TCE and the 3 most common cutting-fluid components as aqueous mineral oil (MO) or polyethylene glycol (PEG) mixtures. The cutting-fluid components were 5% linear alkylbenzene sulfonate (LAS), 5% triethanolamine (TEA), and 5% sulfated ricinoleic acid (SRA). In another set of experiments, the diffusion cells were dosed with 14C-Triazine mixtures containing the cutting-fluid components in aqueous MO or PEG-based mixtures after having been pre-exposed in situ to TCE for 96 hours. In the MO-based formulations, the absorption of 14C-Triazine ranged from 3.05 to 3.65% dose. In the PEG-based formulations, the absorption of 14C-Triazine ranged from 2.70 to 4.06% dose. In both sets of experiments, the porcine skin that was pre-exposed in situ to TCE showed greater absorption of 14C-Triazine. The chronic effects of TCE appear to be more important in the PEG-based mixtures than in the MO-based mixtures. [Description provided by NIOSH]
• Subjects:
  Biological Products Dermatitis Environmental Monitoring Occupational Exposure Occupational Health Safety Solvents Workplace
• Keywords:
  Absorption-rates Acute-exposure Biocides Biological-material Chronic-exposure Cleaning-compounds Contact-dermatitis Exposure-assessment Exposure-levels In-vitro-studies Occupational-exposure Triazines Work-environment Worker-health Workers

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• ISSN:
  1096-6080
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  Louisiana ; North Carolina ; OSHA Region 4 ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  445-446
• Volume:
  84
• NIOSHTIC Number:
  nn:20026504
• Citation:
  Toxicologist 2005 Mar; 84(Suppl 1):445-446
• CAS Registry Number:
  Trichloroethylene (CAS RN 79-01-6)
• Federal Fiscal Year:
  2005
• NORA Priority Area:
  Disease and Injury: Allergic and Irritant Dermatitis
• Performing Organization:
  North Carolina State University, Raleigh, North Carolina
• Peer Reviewed:
  False
• Start Date:
  20000801
• Source Full Name:
  The Toxicologist. Society of Toxicology 44th Annual Meeting and ToxExpo, March 6-10, 2005, New Orleans, Louisiana
• Supplement:
  1
• End Date:
  20150731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:709dd70e08b990d2be35584ac457a21f7be8593ae16235b201df869a98367b363a8141cdac997a6c0781c3bdab4c21b1008e57f6741ff7fc8720ea6049df8857
• Download URL:
  https://stacks.cdc.gov/view/cdc/197313/cdc_197313_DS1.pdf
• File Type:
  [PDF - 336.24 KB ]