Effect of Metal Working Formulations on Biocide Absorption in a PDMS Membrane Coated Fiber

Details

• Personal Author:
  Barlow BM ; Baynes RE
• Description:
  Biocides and preservatives are commonly used in metal working industry applications as additives to extend the shelf life of commercially manufactured aqueous metal working fluid (MWF) formulations. While little is known of the dermal absorption and disposition of these and other MWF formulation components, 5 major classes of these biocides have been associated with occupational contact dermatitis (OCD) in metal machine workers exposed to these mixtures. A PDMS membrane coated fiber (MCF) was exposed to three industrial generic aqueous cutting fluid formulations; soluble oil (SO), semi-synthetic oil (SSYN), and synthetic oil (SYN), as well as surrogate formulations of PEG-200 (PEG) and mineral oil (MO) (to mimic synthetic and soluble oil formulations respectively) at three different concentrations (0.05%, 0.5%, and 5%) to determine the absorption of 37 solutes, including representatives from each of the 5 classes of biocides known to cause OCD. Log Kmcf values were used to quantify dermal absorption and to determine differences between the formulation and/or concentrations. Initial trends indicate that highest absorption occurs at the lowest concentration (absorption at 0.05%> 0.5%>5.0%) across formulations. This trend is best demonstrated in soluble oil (SO) formulation, and Log Ko/w values best correlated with the 0.05% concentration (R2 = 0.77). Changes in absorption of solutes with low log Ko/w values were less likely to be influenced by changes in MWF concentrations, while changes in absorption were magnified at higher Log Ko/w values. The biocide 4-tertiary amylphenol showed its most pronounced absorption difference between the 3 concentrations in the MO formulation, followed by SO, SYN, and then PEG; the later with little or no difference in absorption between the concentrations. These phenomena suggest that there is not only a chemical but also concentration dependent influence on absorption of individual solutes in the presence of more complex formulations or mixtures. [Description provided by NIOSH]
• Subjects:
  Aerosols Air Movements Chemistry Dermatitis Environmental Monitoring Hypersensitivity Metals Metal Workers Occupational Exposure Occupational Health Safety Skin Skin Diseases Workplace

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• Keywords:
  Absorption-rates Air-flow Biocides Chemical-hypersensitivity Chemical-properties Chemical-reactions Contact-allergies Contact-dermatitis Exposure-assessment Exposure-levels Exposure-methods Metallic-compounds Metalworking Metalworking-fluids Metalworking-industry Occupational-dermatitis Occupational-exposure Occupational-hazards Occupational-health Skin-exposure Skin-irritants Skin-sensitivity Statistical-analysis Worker-health Workplace-studies

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• ISSN:
  1096-6080
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  North Carolina ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  23
• Volume:
  108
• Issue:
  1
• NIOSHTIC Number:
  nn:20035213
• Citation:
  Toxicologist 2009 Mar; 108(1):23
• Contact Point Address:
  Ronald E. Baynes, Center for Chemical Toxicology Research and Pharmacokinetics (CCTRP), College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
• Federal Fiscal Year:
  2009
• NORA Priority Area:
  Disease and Injury: Allergic and Irritant Dermatitis
• Performing Organization:
  North Carolina State University, Raleigh, North Carolina
• Peer Reviewed:
  False
• Start Date:
  20000801
• Source Full Name:
  The Toxicologist. Society of Toxicology 48th Annual Meeting and ToxExpo, March 15-19, 2009, Baltimore, Maryland
• End Date:
  20150731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:571d0dbde1e14af631213b9fab65b50024b42c7a9ecb6aac004d1001e27b6efd48ed5077c550e8395ed81f2ba201fbb86cac7764d169229c7f166e30e365e5f6
• Download URL:
  https://stacks.cdc.gov/view/cdc/187138/cdc_187138_DS1.pdf
• File Type:
  [PDF - 1.01 MB ]