Measurement of Freon-113 Exposure Dose in Exhaled Breath Samples Using GC/MS with Preconcentration

Details

• Personal Author:
  Shaffer, Richard A. ; Viscusi DJ ; Zhuang ZQ
• Description:
  In previous work involving half-mask respirators, NIOSH found a correlation between fit factor (a quantitative measure of respirator performance) and total Freon-113 exposure dose (TFED), the amount of Freon-113 in a subject's end-exhaled breath measured 30 minutes after a simulated workplace test. Better detection methods for Freon-113 need to be developed in order to investigate the correlation for other classes of respirators. In this presentation we will describe improved strategies for measuring TFED using gas chromatography-mass spectrometry (GC-MS) with a preconcentration system. This presentation will describe column selection, detection limits, and precision of the analytical method. The effect of critical environmental parameters such as the background level of Freon-113 in the room will also be assessed. The use of GC/MS with preconcentration for exhaled breath analysis and trace detection may find suitability in other applications such as biomarker discovery, industrial hygiene and environmental monitoring. [Description provided by NIOSH]
• Subjects:
  Biomarkers Occupational Health Personal Protective Equipment Refrigeration Respiratory Protective Devices Safety
• Keywords:
  Analytical-methods Analytical-processes Industrial-hygiene Refrigerants Respirators Respiratory-protective-equipment Sample-preparation Sampling Sampling-methods
• ISSN:
  0065-7727
• Document Type:
  Text
• Genre:
  Abstract or Summary ; Proceedings
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  NPPTL - National Personal Protective Technology Laboratory
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  228
• NIOSHTIC Number:
  nn:20026153
• Citation:
  Abstr Pap - Am Chem Soc 2004 Aug; 228(Pt 1):ANYL-083
• Contact Point Address:
  NIOSH/NPPTL, 626 Cochrans Mill Road, Pittsburgh, PA 15236
• Email:
  dcv6@cdc.gov
• Federal Fiscal Year:
  2004
• Peer Reviewed:
  False
• Part Number:
  1
• Source Full Name:
  Abstracts of papers - American Chemical Society
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:36d18c5e0245a9e16a0b0936ddf88352d84143e8e3b193adb201a0cba01a815d3bb4f099cdb28bf0317802d10af58b7ee4167359026e14325d93ac3bc4d39b23
• Download URL:
  https://stacks.cdc.gov/view/cdc/197214/cdc_197214_DS1.pdf
• File Type:
  [PDF - 212.99 KB ]