Chronic Obstructive Pulmonary Disease. Mechanisms of Disease Development and Prevention Strategies with Antioxidants

Details

• Personal Author:
  Daga MK ; Vallyathan V
• Description:
  To summarize, one can say with certainty that COPD develops in genetically susceptible individuals after prolonged exposure to cigarette smoke. Presently, most of the genes contributing to this are unknown. Alpha1-A T deficiency is a risk factor for COPD, but other genetic associations with this disease must still be considered as tentative. The key to establishing that a gene modifies the risk for a disease is replication of the association in different populations. This is a difficult task. Besides alpha1-AT, only the GST-Ml, VDBP, and CFTR genes have been implicated as risk factors in more than one population. Identification of other candidate genes would further enhance the understanding of COPD pathogenesis at the molecular level. There is also good evidence that the propensity to smoke cigarettes and the likelihood of quitting smoking are influenced by genetic factors. This can be useful in efforts directed at cessation of smoking. The responses to hypoxia and hypercapnia also seem to be influenced by genetic factors. Identification of the genes involved could yield important insights into the pathogenesis of COPD and provide new targets for therapeutic interventions for this debilitating disease. [Description provided by NIOSH]
• Subjects:
  Antioxidants Carcinogens Chronic Disease Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety Smoke Smokers Tobacco Products

  More +
• Keywords:
  Antioxidation Carcinogenesis Chronic-degenerative-diseases Cigarette-smoking Lung-disease Lung-disorders Lung-function Pulmonary-function Pulmonary-system-disorders Respiratory-system-disorders Tobacco-smoke

  More +
• ISBN:
  9780824748746
• Publisher:
  Marcel Dekker
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  361-391
• Volume:
  187
• NIOSHTIC Number:
  nn:20025838
• Citation:
  Oxygen/nitrogen radicals: lung injury and disease (Lung biology in health and disease). Vallyathan V, Castranova V, Shi X, eds. New York: Marcel Dekker, 2004 May; 187:361-391
• Editor(s):
  Vallyathan V; Castranova V; Shi X
• Federal Fiscal Year:
  2004
• NORA Priority Area:
  Research Tools and Approaches: Cancer Research Methods
• Peer Reviewed:
  False
• Source Full Name:
  Oxygen/nitrogen radicals: lung injury and disease (Lung biology in health and disease)
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:21ae48f8365139b2dca373b6c44ae69543311aa947882d2328cdbc69f9494e89b6590bce4738c21cd9af2a846ec1248d40267383818d87445d07097fe1d31754
• Download URL:
  https://stacks.cdc.gov/view/cdc/197049/cdc_197049_DS1.pdf
• File Type:
  [PDF - 2.92 MB ]