Reproductive Factors and Risk of Glioma in Women

Details

• Personal Author:
  Butler MA ; Calvert, Geoffrey M. ; Carreon T ; Davis-King KE ; Deddens J ; Heineman E ; Huang K ; Mandel J ; Morton R ; Reding D ; Rosenman, Kenneth D. ; Ruder, Avima M. ; Schulte P ; Ward, Elizabeth M. ; Waters MA ; Whelan, Elizabeth A. ; Zivkovich Z
• Description:
  Objective: Glioma is the most common primary malignant brain tumor in adults, responsible for 75% of adult primary malignant brain tumors, yet aside from its association with ionizing radiation, its etiology is poorly understood. Sex differences in brain tumor incidence suggest that hormonal factors may play a role in the etiology of these tumors, but few studies have examined this association in detail. The objective of this study was to explore the role of reproductive factors in the etiology of glioma in women. Method: As part of a population-based case-control study, histologically confirmed primary glioma cases (n = 341 women) diagnosed between January 1, 1995 and January 31, 1997 were identified through clinics and hospitals in four Midwest U.S. states. Controls (n = 527 women) were randomly selected from lists of licensed drivers and Health Care Finance Administration enrollees. In-person interviews with subjects (81%) or their proxies (19%) collected reproductive history and other exposure information. Results: Glioma risk increased with older age at menarche (P for trend = 0.009) but only among postmenopausal women. Compared with women who never breast-fed, women who breast-fed >18 months over their lifetime were at increased risk of glioma (odds ratio, 1.8; 95% confidence interval, 1.1-2.9). Women who reported using hormones for symptoms of menopause had a decreased risk of glioma compared with women who never used such hormones (odds ratio, 0.7; 95% confidence interval, 0.5-1.1). Conclusion: These results support the hypothesis that reproductive hormones play a role in the etiology of glioma among women. [Description provided by NIOSH]
• Subjects:
  Agriculture Demography Endocrine System Endocrine System Diseases Farmers Histology Insecticides Neoplasms Nervous System Nervous System Diseases Occupational Health Safety Sex Characteristics Urogenital Diseases Urogenital System

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• Keywords:
  Agricultural-chemicals Brain-disorders Brain-function Brain-matter Brain-tumors Central-nervous-system Demographic-characteristics Endocrine-function Endocrine-system Endocrine-system-disorders Exposure-levels Exposure-limits Hormone-activity Hormones Neurotoxicity Pesticide-residues Pesticides Pesticides-and-agricultural-chemicals Reproductive-effects Reproductive-hazards Sex-factors

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• ISSN:
  1055-9965
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; EID - Education and Information Division ; DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  13
• Issue:
  10
• NIOSHTIC Number:
  nn:20025717
• Citation:
  Cancer Epidemiol Biomark Prev 2004 Oct; 13(10):1583-1588
• Contact Point Address:
  Elizabeth A. Whelan, Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-15, Cincinnati, OH 45226
• Email:
  EWhelan@cdc.gov
• Federal Fiscal Year:
  2005
• Peer Reviewed:
  True
• Source Full Name:
  Cancer Epidemiology, Biomarkers & Prevention
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:63ad7e4ff3603574821f114c7a6a49963b0d5c351808cf42b2af0b7d1a4a1b8fcd506e26051591ab9e83241fc246ad9d0a97bdb9e9e685d45e7f7ce3dbd1c0a5
• Download URL:
  https://stacks.cdc.gov/view/cdc/196978/cdc_196978_DS1.pdf
• File Type:
  [PDF - 184.16 KB ]