Reproductive Factors and Risk of Glioma in Women

Details

• Personal Author:
  Brain Cancer Collaborative Study Group ; Butler MA ; Calvert, Geoffrey M. ; Carreon T ; Davis-King KE ; Deddens J ; Heineman E ; Huang K ; Mandel J ; Morton R ; Reding D ; Rosenman, Kenneth D. ; Ruder, Avima M. ; Schulte P ; Ward, Elizabeth M. ; Waters MA ; Whelan, Elizabeth A. ; Zivkovich Z
• Description:
  Reproductive hormones may play a role in the development of glioma in women, but few studies have examined this association. As part of a population-based case control study, histologically confirmed primary glioma cases (n=341 women) diagnosed between 1995 and 1997 were identified through clinics and hospitals in four Midwest U.S. states. Controls (n=528 women) were randomly selected from lists of licensed drivers and Health Care Finance Administration enrollees. In-person interviews with subjects (81%) or their proxies (19%) collected reproductive history and other exposure information. Glioma risk increased with older age at menarche (p for trend = 0.0076), but only among post-menopausal women. Among pre-menopausal women, those who had ever experienced a live birth were over two times as likely to be diagnosed with glioma than were nulliparous women (odds ratio (OR)=2.7, 95% confidence interval (95% CI)=1.3-5.3). Compared with women who breastfed 1-3 months over their lifetime, women who breastfed 4-8, 9-18 or 18 months were at increased risk (OR=1.6, 95% CI=0.7-3.9; OR=3.0, 95% CI=1.4-6.5; OR=4.6, 95% CI=2.1-10.2; respectively) (p for trend=0.0008). Women who used hormones for symptoms of menopause had a significantly decreased risk of glioma compared with women who never used such hormones (OR=0.6; 95% CI=0.4-0.9). A high cumulative number of menstruation months (438) was also associated with a reduced risk of glioma (OR=0.6, 95% CI=0.3-1.3). Our results support the hypothesis that reproductive hormones play a role in the etiology of glioma among women, with a pattern of associations that is almost the inverse of that observed for breast cancer. [Description provided by NIOSH]
• Subjects:
  Agriculture Demography Endocrine System Endocrine System Diseases Farmers Histology Insecticides Neoplasms Nervous System Nervous System Diseases Occupational Health Safety Sex Characteristics Urogenital Diseases Urogenital System

  More +
• Keywords:
  Agricultural-chemicals Brain-disorders Brain-function Brain-matter Brain-tumors Central-nervous-system Demographic-characteristics Endocrine-function Endocrine-system Endocrine-system-disorders Exposure-levels Exposure-limits Hormone-activity Hormones Neurotoxicity Pesticide-residues Pesticides Pesticides-and-agricultural-chemicals Reproductive-effects Reproductive-hazards Sex-factors

  More +
• ISSN:
  0197-016X
• Publisher:
  American Association for Cancer Research
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  44
• NIOSHTIC Number:
  nn:20024124
• Citation:
  Proceedings of the American Association for Cancer Research (AACR) 94th Annual Meeting, July 11-14, 2003, Washington, DC. 2nd edition. Philadelphia, PA: American Association for Cancer Research, 2003 Jul; 44:1365
• Federal Fiscal Year:
  2003
• Peer Reviewed:
  False
• Source Full Name:
  Proceedings of the American Association for Cancer Research (AACR) 94th Annual Meeting, July 11-14, 2003, Washington, DC
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e9987d5f4ed97de3df77493b51cad5e6efb277b2d7d42c1ffb6a6f7ab5d217dafc6117b1eee705284de84f136eede3065eeae08ed847fd02fb56586214916b2e
• Download URL:
  https://stacks.cdc.gov/view/cdc/196095/cdc_196095_DS1.pdf
• File Type:
  [PDF - 532.81 KB ]