Issues of Design and Analysis in Studies of Gene-Environment Interactions

Details

• Personal Author:
  Bailer AJ ; Carreon T ; Medvedovic M ; Schulte, Paul A. ; Vineis P
• Description:
  The nature-nurture debate has given way to the fundamental realization that both genes and environment play a role in disease, especially cancer. Interaction has been defined in several ways, for example as "the coparticipation of two or more agents in the same causal mechanism leading to disease development" (Yang and Khoury, 1997). According to a more generally accepted definition, interaction occurs when the effect of multiple factors differ from the effect predicted on the basis of the separate effects of each of the factors. [Description provided by NIOSH]
• Subjects:
  Carcinogens Environmental Health Epidemiology Genetics Neoplasms Occupational Health Safety
• Keywords:
  Cancer Carcinogenesis Carcinogenicity Diseases Environmental-factors Genes
• ISBN:
  9283221575
• Publisher:
  IARC Press
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  417-435
• Issue:
  157
• NIOSHTIC Number:
  nn:20025620
• Citation:
  Mechanisms of Carcinogenesis: Contributions of Molecular Epidemiology, IARC Publication No. 157. Lyon, France: International Agency for Research on Cancer, 2004; 157:417-435
• Email:
  paolo.vineis@unito.it
• Editor(s):
  Buffler P; Rice J; Baan R; Bird M; Boffetta P
• Federal Fiscal Year:
  2004
• Peer Reviewed:
  False
• Source Full Name:
  Mechanisms of Carcinogenesis, Contributions of Molecular Epidemiology, IARC Publication No. 157.
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:296d24ff4c29a2a2595a5e68c6d42e244b100122fe80cb67cd0035eb07496a6d59b88dcda2606bf813392a398dd019aa51ab4198309a631215754a98bd19e0c7
• Download URL:
  https://stacks.cdc.gov/view/cdc/196904/cdc_196904_DS1.pdf
• File Type:
  [PDF - 2.94 MB ]