Arsenic and Atherosclerosis

Details

• Personal Author:
  Luster MI ; Simeonova PP
• Description:
  Epidemiological studies have demonstrated a correlation between environmental or occupational arsenic exposure and a risk of vascular diseases related to atherosclerosis. Studies summarized in this review suggest that arsenic induces endothelial dysfunction, including inflammatory and coagulating activity as well as impairs nitric oxide (NO) balance. This may provide the pathophysiological basis for atherogenic potential of arsenic. Consistent with these data, arsenic accelerates atherosclerosis in apolipoprotein E (ApoE) deficient mice, a model of human atherosclerosis. [Description provided by NIOSH]
• Subjects:
  Animals Arsenic Cardiovascular Diseases Cardiovascular System Environment Environmental Exposure Epidemiology Inorganic Chemicals Laboratories Occupational Exposure Occupational Health Risk Assessment Risk Factors Safety

  More +
• Keywords:
  Animal-studies Arsenic-compounds Author Keywords: Arsenic Toxicity Cardiovascular-disease Cardiovascular-system Cardiovascular-system-disease Cardiovascular-system-disorders Cardiovascular Toxicity Environmental-exposure Environmental Factors Inflammation Laboratory-animals Occupational-exposure Risk-analysis Risk-factors Vascular Diseases Veins

  More +
• ISSN:
  0041-008X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  444-449
• Volume:
  198
• Issue:
  3
• NIOSHTIC Number:
  nn:20025476
• Citation:
  Toxicol Appl Pharmacol 2004 Aug; 198(3):444-449
• Contact Point Address:
  Tissue Injury Team, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505
• Email:
  psimeonova@cdc.gov
• CAS Registry Number:
  Nitric oxide (CAS RN 10102-43-9)
• Federal Fiscal Year:
  2004
• Peer Reviewed:
  True
• Source Full Name:
  Toxicology and Applied Pharmacology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:31c39b327812d606510e6f72732b55e52171d0f1aef512e19ca28398bec6396f3a8b3a49574abae274f9d0e1cacab4e98b7883740a8eb60b0b5f22d810481b69
• Download URL:
  https://stacks.cdc.gov/view/cdc/196824/cdc_196824_DS1.pdf
• File Type:
  [PDF - 189.36 KB ]