Evaluation of the Prevalence of Antiwheat-, Anti-Flour Dust, and Anti-Alpha-Amylase Specific IgE Antibodies in US Blood Donors

Details

• Personal Author:
  Biagini, Raymond E. ; MacKenzie, Barbara A. ; Robertson SK ; Sammons DL ; Smith JP ; Snawder, John E. ; Striley CAF
• Description:
  Asthma in bakery workers is one of the most frequently occurring forms of occupational asthma in the world. Experience from other countries has shown the prevalence of sensitization (IgE) to bakery-associated allergens (BAAs) (wheat [W], flour dust [FD], alpha-amylase [AA]) in bakery workers to be 5% to 53%, whereas the prevalence in nonoccupationally exposed individuals was estimated to be 1.2% to 6.4%. To estimate the prevalence of BAA sensitization by measuring BAA specific IgE in the residual serum tubes of volunteer blood donors. METHODS: Serum samples from 534 volunteer blood donors were measured for anti-W, anti-FD, and anti-AA specific IgE antibodies (in duplicate) using the AlaSTAT microplate assay. Samples with BAA IgE concentrations of 0.35 kU/L or greater were considered positive. Nineteen of 530 serum samples (3.6%; 95% confidence interval [CI], 3.3%-3.9%) were positive for W (range, 0.38-3.61 kU/L), whereas 31 of 534 (5.8%; 95% CI, 5.3%-6.3%) were positive for FD (range, 0.35-2.34 kU/L) and 5 of 529 (1.0%; 95% CI, 0.9%-1.1%) were positive for AA (range, 0.38-1.59 kU/L). Thirteen serum samples were positive for both W and FD; 1 sample each was positive for W and AA and FD and AA. The prevalence of IgE sensitization in serum samples from a relatively large unselected population of volunteer blood donors is 1.0% for AA, 3.6% for W, and 5.8% for FD, which agrees well with data from other countries for sensitization prevalence rates for nonoccupationally exposed individuals. [Description provided by NIOSH]
• Subjects:
  Blood Dust Hematologic Tests Hypersensitivity Irritants Occupational Health Respiratory Tract Diseases Safety
• Keywords:
  Allergens Allergic-disorders Allergic-reactions Bakery-workers Blood-sampling Blood-tests Dust-particles Dusts Plant-dusts Respiratory-irritants Respiratory-system-disorders Sensitization

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• ISSN:
  1081-1206
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  92
• Issue:
  6
• NIOSHTIC Number:
  nn:20025383
• Citation:
  Ann Allergy Asthma Immunol 2004 Jun; 92(6):649-653
• Contact Point Address:
  National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio 45226
• Email:
  rbiagini@cdc.gov
• CAS Registry Number:
  2-[(1-Methylethoxy)methyl]oxirane (CAS RN 4016-14-2)
• Federal Fiscal Year:
  2004
• NORA Priority Area:
  Research Tools and Approaches: Exposure Assessment Methods
• Peer Reviewed:
  True
• Source Full Name:
  Annals of Allergy, Asthma and Immunology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:85f2e10bd13595c07299ebc58009f3b8e6cf714fd4ac48041724f36bdbe8009cd93845ac21db4594f56eeacaa02f0b6d32a69dee178e7559d893d6526f1940f1
• Download URL:
  https://stacks.cdc.gov/view/cdc/196779/cdc_196779_DS1.pdf
• File Type:
  [PDF - 244.45 KB ]