Pulmonary Inflammation and Fibrosis in Rats After Intratracheal Instillation of Adipic Acid and Adipic Acid Mixtures

Details

• Personal Author:
  Barger M ; Battelli LA ; Castranova, Vincent ; Cocalis, Joseph C. ; Frazer D ; Goldsmith WT ; Hubbs, Ann F. ; Ma JYC ; Porter DW ; Robinson VA ; Vallyathan V
• Description:
  Adipic acid is an aliphatic dicarboxylic acid which can be added to food in small quantities and is used for several other commercial purposes. During me production of polymers and in the sheet glass industry, respiratory exposures occur. There is no OSHA PEL for adipic acid and it has little or no odor. We have investigated the hypothesis that respiratory exposures to adipic acid are non-toxic. We conducted intratracheal instillation exposures to adipic acid and adipic acid mixtures at levels which would produce limited disease and no monality with nuisance dusts. Intratracheal instillation of 2.5, 5, or 7 mgs of adipic acid in rats produced acute pulmonary cytotoxicity and inflammation. One day after instillation. lavage protein. LDH, and inflammtory cells were markedly increased. Histopathology confirmed acute pulmonary inflammation. Four weeks after exposure, pulmonary alterations persisted and were most pronounced in the rats receiving 7 mgs of adipic acid. Significant changes included bydroxyproline increases, histologic foci of pulmonary fibrosis, and persistent tachypnea. Neutralization of the pH ameliorated the toxicity. These findings suggest that high concentrations of adipic acid can cause persistent pulmonary structural and functional alterations. The proposed mechanism is the acidity and lipid solubility of this organic acid. Inhalation studies are planned. [Description provided by NIOSH]
• Subjects:
  Animals Dicarboxylic Acids Irritants Laboratories Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Animal-studies Dicarboxylic-acids Histopathology Laboratory-animals Organic-acids Pulmonary-disorders Pulmonary-system Pulmonary-system-disorders Respiratory-infections Respiratory-irritants Respiratory-system-disorders

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• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 10 ; OSHA Region 3 ; Washington ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  42
• NIOSHTIC Number:
  nn:20025097
• Citation:
  Toxicologist 1998 Mar; 42(1-S):251
• CAS Registry Number:
  Adipic acid (CAS RN 124-04-9)
• Federal Fiscal Year:
  1998
• Peer Reviewed:
  False
• Source Full Name:
  The Toxicologist. Society of Toxicology 37th Annual Meeting, March 1-5,1998, Seattle, Washington
• Supplement:
  1-S
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ead0a97f758ef1802afe6acd65b582154a874f7687b90a5f58f25451feeb42caf33417a49d8e263400692879ec239a129b09d10e57124ea902dd3730dd21f12a
• Download URL:
  https://stacks.cdc.gov/view/cdc/196594/cdc_196594_DS1.pdf
• File Type:
  [PDF - 149.58 KB ]