Tuberculosis Mortality and Silica Exposure: A Case-Control Study Based on a National Mortality Database for the Years 1983–1992

Details

• Personal Author:
  Alterman, Toni ; Althouse RB ; Burnett CA ; Cameron, Lorraine L. ; Chen GX ; Lalich NR ; Tanaka, Shiro
• Description:
  A case-control study (8,740 cases; 83,338 controls) was done to evaluate the association between potential occupational exposure to silica and risk of tuberculosis (TB) mortality, using the National Occupational Mortality Surveillance database for 1983-1992. Potential silica exposure was based on the decedent's usual industry and occupation. Assignment of potential exposure to silica was based on the entire range of industries and occupations. Odds ratios (ORs) for mortality from respiratory TB associated with potential high and intermediate exposures to silica were 1.30 (95% CI 1.14-1.48) and 1.07 (95% CI 0.77-1.47), respectively, adjusting for silicosis, other pneumoconioses, age, gender, race, socioeconomic status, and potential exposure to active TB. The elevated OR was seen in all subgroups: male, female, white, and black. The average age at death among respiratory TB cases with potential silica exposure was significantly younger by four years than that among cases without potential silica exposure. The findings suggest that potential occupational exposure to silica alone, in the absence of silicosis, is associated with respiratory TB mortality, with a dose-response relationship. Description provided by NIOSH
• Subjects:
  • Epidemiology
  • Irritants
  • Mortality
  • Occupational Health
  • Pneumoconiosis
  • Respiratory Tract Diseases
  • Safety
  • Silicon Dioxide
  • Silicosis
• Keywords:
  • Silica-dusts
  • Mortality-data
  • Mortality-rates
  • Respiratory-irritants
  • Respiratory-system-disorders
  • Statistical-analysis
  • Epidemiology
  • NOMS
  • National Occupational Mortality Surveillance
  • Author Keywords: silica
  More +
• ISSN:
  1077-3525
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 3 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  163-170
• Volume:
  3
• Issue:
  3
• NIOSHTIC Number:
  nn:20024993
• Citation:
  Int J Occup Environ Health 1997 Jul; 3(3):163-170
• Contact Point Address:
  Carol A. Burnett, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
• Federal Fiscal Year:
  1997
• Peer Reviewed:
  True
• Source Full Name:
  International Journal of Occupational and Environmental Health
• Download URL:
  https://stacks.cdc.gov/view/cdc/196533/cdc_196533_DS1.pdf
• File Type:
  [PDF - 1.98 MB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8e19da061b79a1acd0b775db3e6eedbc3ae6e8d581d3c9f9535e90e6c275486a27d2d69221a0f8dd0988cd564601078efddc36790ab70906012e1ee3bd181876