Bronchoalveolar Lavage Macrophage-Lymphocyte Clusters in Granulomatous Disease Are Linked to Lymphocytosis

Details

• Personal Author:
  Balkissoon R ; Bauer RA ; Daniloff E ; Newman, Lee S. ; Rose CS ; Sawyer RT
• Description:
  Clusters of macrophages associated with lymphocytes (ML clusters) have been observed among the bronchoalveolar lavage (BAL) cells of patients with pulmonary disease. We tested the hypothesis that ML clusters might be found among the BAL cells from patients with granulomatous disease. We measured the number of ML clusters among the BAL cells from normal controls (n = 13), sarcoidosis patients (n = 18), beryllium-sensitized (BeS) patients (n = 21) and chronic beryllium disease (CBD) patients (n = 15). ML clusters were observed in the BAL cells of all groups, but at different frequencies: normal 8.5% (median, range 2-15%); BeS 7% (range 2-31%); sarcoidosis 14% (range 4-50%); and CBD 17% (range 6-73%). This data suggested that ML clusters were increased in granulomatous lung disease. However, the percentage of ML clusters strongly correlated with the BAL lymphocyte percentage (rho = 0.79). Cohort analysis showed that increases in macrophages having 2, 3 or > 3 associated lymphocytes correlated with an increase in lymphocyte percentage. An increase in ML clusters in BAL cells is not specific for granulomatous disease and is associated with the increase in BAL lymphocytes. [Description provided by NIOSH]
• Subjects:
  Beryllium Blood Cytology Immune System Lung Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Alveolar-cells Author Keywords: Beryllium Beryllium-compounds Beryllium-disease Cell-function Chronic Beryllium Disease Disease Granulomatous Immunology Lymphocytes Macrophage-Lymphocyte Clusters Pulmonary-system-disorders Respiratory-system-disorders Sarcoidosis

  More +
• ISSN:
  1124-0490
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  174-180
• Volume:
  17
• Issue:
  2
• NIOSHTIC Number:
  nn:20024247
• Citation:
  Sarcoidosis Vasc Diffuse Lung Dis 2000 Jun; 17(2):174-180
• Contact Point Address:
  National Jewish Medical and Research Center, Division of Environmental and Occupational Health Sciences, 1400 Jackson Street, Denver, CO 80206
• CAS Registry Number:
  Beryllium (CAS RN 7440-41-7)
• Federal Fiscal Year:
  2000
• Performing Organization:
  National Jewish Medical and Research Center, Division of Environmental and Occupational Health Sciences, Denver, Colorado 80206
• Peer Reviewed:
  True
• Start Date:
  20010601
• Source Full Name:
  Sarcoidosis, Vasculitis, and Diffuse Lung Disease
• End Date:
  20040531
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2ffe7b5844d148339f27f9a0c8bdca7754a63461bbc7e607e567a3a7b6399799482adabab0aec880300eb07b1bfe89709a828a676654b9daef1d15844eb9045b
• Download URL:
  https://stacks.cdc.gov/view/cdc/196156/cdc_196156_DS1.pdf
• File Type:
  [PDF - 758.34 KB ]