Chronic Beryllium Disease: A Model Interaction Between Innate and Acquired Immunity

Details

• Personal Author:
  Kittle LA ; Maier LA ; Newman, Lee S. ; Sawyer RT
• Description:
  Beryllium (Be) is a lightweight and durable metal useful to a variety of manufacturing processes. With the use of Be in industrial settings, a number of health effects were noted including acute pneumonitis, sensitization to Be, interstitial lung disease and dermatological disease. Interstitial mononuclear cell inflammation and granuloma formation are the primary processes that occur in the lungs of Be-exposed workers, resulting in chronic beryllium disease (CBD). Recent studies have begun to describe the role of Be in the pathogenesis of CBD. These studies reveal that the host's response to Be involves components of the innate immune system or inflammatory responses. Inflammatory responses to Be can establish a state of acquired, Be antigen-specific, cell-mediated immunity. Despite triggering both the innate and acquired immune responses, Be is not eliminated from the host. Rather, it establishes pathways leading to chronic granulomatous inflammation. We will examine recent studies describing the host's cellular and molecular responses to Be, responses that promote granuloma formation. [Description provided by NIOSH]
• Subjects:
  Beryllium Chronic Disease Immune System Lung Lung Diseases Occupational Exposure Occupational Health Respiratory System Safety
• Keywords:
  Beryllium-compounds Beryllium-disease Cellular-reactions Chronic-exposure Chronic-inflammation Immune-reaction Immune-system Immunology Lung-cells Lung-disorders
• ISSN:
  1567-5769
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  249-261
• Volume:
  2
• Issue:
  2
• NIOSHTIC Number:
  nn:20024241
• Citation:
  Int Immunopharmacol 2002 Feb; 2(2-3):249-261
• Contact Point Address:
  National Jewish Medical and Research Center, Department of Medicine, 1400 Jackson Street, Denver, CO 80206
• Email:
  sawyerr@njc.org
• CAS Registry Number:
  Beryllium (CAS RN 7440-41-7)
• Federal Fiscal Year:
  2002
• Performing Organization:
  National Jewish Medical and Research Center, Department of Medicine, Denver, Colorado
• Peer Reviewed:
  True
• Start Date:
  19950930
• Source Full Name:
  International Immunopharmacology
• End Date:
  20000929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9c65cb18b1ddd2c390d53b60acbff56ab5d473e9520e823227c56da4822f972cc485589e24b2f0e700d166c0ff8b3602385a9478584c544a6f8bba1677a91956
• Download URL:
  https://stacks.cdc.gov/view/cdc/196151/cdc_196151_DS1.pdf
• File Type:
  [PDF - 177.52 KB ]