Role of Nitric Oxide in the Progression of Pneumoconiosis

Details

• Personal Author:
  Castranova, Vincent ; Castranova, Vincent
• Description:
  Conflicting evidence has been reported as to whether nitric oxide (NO) possesses anti-inflammatory or inflammatory properties. Data are presented indicating that in vitro or in vivo exposure to selected occupational dusts, i.e., crystalline silica, organic dust contaminated with endotoxin, or asbestos, results in upregulation of inducible ntric oxide synthase (iNOS) and the production of NO by alveolar macrophages and pulmonary epitelial cells. Nitric oxide production is assocated temporarilly and anatomically with pulmonary damange, inflammation, and disease progression in response to occupational dusts. Blockage of inducible ntric oxide synthase by administration of NOS inhibitors or in iNOS knockout mice decreases the magnitude of injury and inflammation following in vivo exposure to silica, endotoxin, or asbestos. Therefore, NO may play an important role in the initiation and progression of pneumoconiosis. [Description provided by NIOSH]
• Subjects:
  Asbestos Dust Endotoxins Inorganic Chemicals Nitrogen Compounds Occupational Exposure Occupational Health Pneumoconiosis Safety Silicon Dioxide
• Keywords:
  Asbestos Asbestos-dust Asbestosis Author Keywords: Silicosis Byssinosis Cotton Dust Crystalline Silica Dust-exposure Endotoxin In-vitro-study In-vivo-study INOS LPS Nitric Oxide Nitrogen-compounds Occupational-exposure Silica-dusts

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• ISSN:
  0006-2979
• Document Type:
  Text
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  32-37
• Volume:
  69
• Issue:
  1
• NIOSHTIC Number:
  nn:20024239
• Citation:
  Biochemistry (Moscow) 2004 Jan; 69(1):32-37
• Contact Point Address:
  V. Castranova, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
• Email:
  vic1@cdc.gov
• Federal Fiscal Year:
  2004
• Peer Reviewed:
  True
• Source Full Name:
  Biochemistry (Moscow)
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1f6b4be8e4bb6bc290d41b4ce804c3487d8d9e5d34f2af6d9f239d797ec5e26f548fed62962d9dfd6a09a657b6b18c49701439f40d14005a73417c654d0a1dcf
• Download URL:
  https://stacks.cdc.gov/view/cdc/196149/cdc_196149_DS1.pdf
• File Type:
  [PDF - 87.27 KB ]