Acute Vibration Exposure Reduces Nitric Oxide (NO) Concentrations and NO-Mediated Vasodilation

Details

• Personal Author:
  Johnson C ; Krajnak, Kristine M. ; Miller R ; Waugh, Stacey
• Description:
  The goal of this study was to determine if vibration affects nitric oxide (NO)-mediated vasodilation in the ventral tail arteries of rats after exposure to a single bout of vibration. Male Sprague Dawley rats were restrained and their tails were exposed to a single 4 h bout of vibration at 125 Hz, 49 m/s2 r. m. s, or control conditions. Vascular levels of the synthetic enzymes, nitric oxide synthase (NOS)-1 and -3 were measured along with vascular NO concentrations. The sensitivity of the ventral artery to NO-induced vasodilation was also assessed in vitro. Exposure to a single bout of vibration reduced NOS-1 and NO concentrations in the ventral tail artery of vibrated animals, and resulted in a reduction in NO-mediated vasodilation that did not appear to be dependent upon endothelial cell activity. The reduced sensitivity of exposed arteries to NO-mediated vasodilation may make these blood vessels more susceptible to damage during subsequent exposures to vibration. [Description provided by NIOSH]
• Subjects:
  Animals Laboratories Occupational Health Safety Vibration
• Keywords:
  Analytical-processes Animal-studies Laboratory-animals Vibration-disease Vibration-effects Vibration-exposure
• Publisher:
  Associazione Italiana di Acustica
• Document Type:
  Text
• Genre:
  Proceedings
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  215-222
• NIOSHTIC Number:
  nn:20032553
• Citation:
  11th International Conference on Hand-Arm-Vibration, June 3-7, 2007, Bologna, Italy. Bovenzi M, Peretti A, Nataletti P, Moschioni-G, eds., Bologna, Italy: Associazione Italiana di Acustica, 2007 Jun; :215-222
• Editor(s):
  Bovenzi M; Peretti A; Nataletti P; Moschioni G
• Federal Fiscal Year:
  2007
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  11th International Conference on Hand-Arm-Vibration, June 3-7, 2007, Bologna, Italy
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2acb3bb89590acb6617772cc9bd9489b1999d2edbabd651934e76f023cd3636f6da83a80ddfaa895ddab14198c66cc04622020afa5d4233bf25d2caff17c6b01
• Download URL:
  https://stacks.cdc.gov/view/cdc/186484/cdc_186484_DS1.pdf
• File Type:
  [PDF - 772.07 KB ]