Resveratrol Scavenges Reactive Oxygen Species and Effects Radical-Induced Cellular Responses

Details

• Personal Author:
  Harris GK ; Jiang B ; Klandorf H ; Leonard, Stephen S. ; Shi X ; Stinefelt B ; Xia C
• Description:
  Scavenging or quenching of the reactive oxygen species (ROS) involved in oxidative stress has been the subject of many recent studies. Resveratrol, found in various natural food products, has been linked to decreased coronary artery disease and preventing cancer development. The present study measured the effect of resveratrol on several different systems involving the hydroxyl, superoxide, metal/enzymatic-induced, and cellular generated radicals. The rate constant for reaction of resveratrol with the hydroxyl radical was determined, and resveratrol was found to be an effective scavenger of hydroxyl, superoxide, and metal-induced radicals as well as showing antioxidant abilities in cells producing ROS. Resveratrol exhibits a protective effect against lipid peroxidation in cell membranes and DNA damage caused by ROS. Resveratrol was also found to have a significant inhibitory effect on the NF-kB signaling pathway after cellular exposure to metal-induced radicals. It was concluded that resveratrol in foods plays an important antioxidant role. [Description provided by NIOSH]
• Subjects:
  Antioxidants Lipids Neoplasms Occupational Health Oxidants Safety
• Keywords:
  Author Keywords: Resveratrol Cancer Rates Cellular Reactions Cr(VI) DNA Damage Hydroxyl Groups Hydroxyl Radicals Lipid Peroxidation NF-kB Activation Oxidation Oxidative Processes Superoxide Radicals

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• ISSN:
  0006-291X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  309
• Issue:
  4
• NIOSHTIC Number:
  nn:20023501
• Citation:
  Biochem Biophys Res Commun 2003 Oct; 309(4):1017-1026
• Email:
  SEL5@cdc.gov
• Federal Fiscal Year:
  2004
• Peer Reviewed:
  True
• Source Full Name:
  Biochemical and Biophysical Research Communications
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ebb2dd0b7361fb92902c01eb3601bf19215ecf96efe204d8d64712f507793e063488dfa1e31cbf2e730ea62ce252e75aeca3734f43cbe80bc8111da96f6594e0
• Download URL:
  https://stacks.cdc.gov/view/cdc/195881/cdc_195881_DS1.pdf
• File Type:
  [PDF - 409.77 KB ]