A Derived Association Between Ambient Aerosol Surface Area and Excess Mortality Using Historic Time Series Data

Details

• Personal Author:
  Maynard AD ; Maynard RL
• Description:
  Although aerosol mass concentration is widely associated with ill health following inhalation; there is increasing evidence that it is a poor indicator of fine and ultrafine particle toxicity. Research has indicated that biological response to such particles is closely associated with particulate surface area; although no epidemiology data currently exist to validate the association. By applying a simple model to historic mass-based time series data, we have been able to estimate mortality rate as a function of ambient aerosol surface area. Within the simplifying assumptions of the model, a linear association is indicated between mortality rate and surface area concentration for coalescing particles. The analysis also indicates the existence of a threshold aerosol concentration, below which particulate mass and surface area are linearly related. Below this threshold, we suggest that mass concentration measurements may provide a good indicator of health effects, although for high exposures found in the developing world and industry, the model indicates that aerosol exposure may be more appropriately characterized by surface area. Further experimental validation of the model should establish the applicability of derived relationships between aerosol mass and surface area concentration to ambient and occupational exposures. [Description provided by NIOSH]
• Subjects:
  Aerosols Environmental Exposure Mortality Occupational Exposure Occupational Health Particulate Matter Respiratory System Safety
• Keywords:
  Author Keywords: Aerosol Computational Modeling Exposure Exposure Levels Health Effects Inhalation Studies Models Mortality Data Mortality Rates Nanotechnology Occupational Exposure Particulates Surface Area

  More +
• ISSN:
  1352-2310
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  36
• Issue:
  36
• NIOSHTIC Number:
  nn:20023497
• Citation:
  Atmos Environ 2002 Dec; 36(36-37):5561-5567
• Contact Point Address:
  US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Applied Research and Technology, 4676 Columbia Parkway, Cincinnati, OH 45226
• Email:
  zel5@cdc.gov
• Federal Fiscal Year:
  2003
• NORA Priority Area:
  Research Tools and Approaches: Exposure Assessment Methods
• Peer Reviewed:
  True
• Source Full Name:
  Atmospheric Environment
• End Date:
  20040930
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:521f37c26425662c30e9a52251272053c8e2850f90b14e1e8a2343c167de3184fc6d651dea218871847c1dd0fb0618144547cb4e97cf597dfaa89dc7448f610f
• Download URL:
  https://stacks.cdc.gov/view/cdc/195877/cdc_195877_DS1.pdf
• File Type:
  [PDF - 183.07 KB ]