Synthesis Characterization and Use of 2-[(2H9)butoxy]acetic Acid and 2-(3-Methylbutoxy)acetic Acid as an Internal Standard and an Instrument Performance Surrogate Respectively for the Gas Chromatographic-Mass Spectrometric Determination of 2-Butoxyac

Details

• Personal Author:
  Brown KK ; Butler MA ; Cheever KL ; McLaurin JL ; Shaw, Peter B.
• Description:
  2-[(2H9)Butoxy]acetic acid and 2-(3-methylbutoxy)acetic acid were synthesized, mixed with 2-butoxyacetic acid, and separated by capillary gas chromatography on a fused-silica column with a length of 50 m, inside diameter of 0.200 mm, and a "free fatty acid phase" wall coating of 0.3 um film. 2-[(2H9)Butoxy]acetic acid, 2-butoxyacetic acid, and 2-(3-methylbutoxy)acetic acid were baseline resolved at retention times of 13.55, 13.78, and 15.20 min; 2-(3-methylbutoxy)acetic acid having a peak efficiency of 360000. Mass spectrometric detection using selected ion monitoring at m/z 66, 57, and 71 showed linear analytical responses from 0.04 ng to at least 200 ng with a limit of detection of 0.04 ng for 2-butoxyacetic acid. [Description provided by NIOSH]
• Subjects:
  Acids Chemistry Chromatography Energy Metabolism Occupational Health Safety
• Keywords:
  Acetic Acids Author Keywords: 2-Butoxyacetic Acid Chemical Analysis Chemical Reactions Chemical Synthesis Chromatographic Analysis Gas Chromatography Mass Spectrometry Metabolites
• ISSN:
  1570-0232
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  153-166
• Volume:
  792
• Issue:
  2
• NIOSHTIC Number:
  nn:20023485
• Citation:
  J Chromatogr B 2003 Jul; 792(2):153-166
• Contact Point Address:
  National Institute for Occupational Safety and Health (NIOSH), 4676 Columbia Parkway, R-7, Cincinnati, OH 45226, USA
• Email:
  krb1@cdc.gov
• CAS Registry Number:
  2-Butoxyethanol (CAS RN 111-76-2) ; Butoxyacetic acid (CAS RN 2516-93-0)
• Federal Fiscal Year:
  2003
• NORA Priority Area:
  Research Tools and Approaches: Exposure Assessment Methods
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
• End Date:
  20060930
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:506940652cb65909070d261c5e933632761830726855032a34ee644b98a50c0393b99131f7e0a04d076c54ed7d89ae74ae82869e067195b2cf7d6e2177add449
• Download URL:
  https://stacks.cdc.gov/view/cdc/195874/cdc_195874_DS1.pdf
• File Type:
  [PDF - 341.50 KB ]