Alternation of Innate and Cell-Mediated Immunity to Listeria monocytogenes by Short-Term Exposure to Diesel Exhaust Particles

Details

• Personal Author:
  Antonini JM ; Barger MW ; De La Rosa P ; Dong C ; Ma JKH ; Ma JYC ; Roberts, Jennifer R. ; Schafer R
• Description:
  The effects of diesel exhaust particles (DEP) on functions of pulmonary host defense were studied using a rat Listeria infection model. Short-term DEP inhalation (50 and 100 mg/m3, 4 h) by rats resulted in a slowed lung bacterial clearance, suppressed alveolar macrophage (AM) phagocytosis and reduced AM production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-l and IL-12 in response to Listeria. The combined DEP/Listeria exposure was also characterized by increased CD4+ and CD8+ cell counts, and percentage of CD8+ cells in lung draining lymph nodes. The lymphocytes from DEP-treated rats showed increased IL-2 production when challenged with concanavalin A (ConA). Cells from the combined exposed rats produced increased interferon (IFN)-gamma at day 7, but decreased IFN-gamma at day 3, when challenged with either ConA or heat-killed Listeria (HKLM). Listeria significantly induced lymphocyte secretion of IL-6 in response to HKLM, which could be increased by DEP preexposure. These results indicate that short-term DEP exposure aggravates Listeria infection by suppressing AM phagocytosis and the production of TNF-alpha, IL-l and IL-12, and by eliciting an adverse effect on T-cell-mediated immunity. [Description provided by NIOSH]
• Subjects:
  Animals Environmental Exposure Laboratories Lung Lung Diseases Lymphatic System Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Safety Vehicle Emissions

  More +
• Keywords:
  Animal Studies Combustion Gases Diesel Exhausts Exhaust Gases Exposure Levels Laboratory Animals Lung Disorders Lymph Nodes Pulmonary System Disorders Tumors
• ISSN:
  0892-6638
• Document Type:
  Text
• Genre:
  Abstract or Summary ; Proceedings
• Place as Subject:
  Louisiana ; OSHA Region 3 ; OSHA Region 6 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  16
• Issue:
  5
• NIOSHTIC Number:
  nn:20023315 ; nn:20023057
• Citation:
  FASEB J 2002 Mar; 16(5):A962
• Federal Fiscal Year:
  2002
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c939aa9ad45c440b421e6648377f6b62a898d84db0c741ac2fb491fa32b8e65d0c977e1a9c002221f2bcb8affa466322b2e5aa19554801e72f88bba92ef61fa0
• Download URL:
  https://stacks.cdc.gov/view/cdc/195826/cdc_195826_DS1.pdf
• File Type:
  [PDF - 478.99 KB ]