Dose-Response Relationship Between Reach Repetition and Indicators of Inflammation and Movement Dysfunction in a Rat Model of Work-Related Musculoskeletal Disorder

Details

• Personal Author:
  Amin M ; Barbe MF ; Barr AE
• Description:
  The purpose of this study was to compare the effects of a high or low repetition reaching and grasping task on serum levels of interleukin-1alpha. (lL-1alpha.) and IL-1beta and on reach performance in a rat model of work-related musculoskeletal disorder (MSD). Forty-seven rats reached repetitively for 2 hours/day, 3 days/week for 6-8 weeks at a high or low rate. Reach rate and abnormal movement patterns were recorded. Serum was collected at 6 and 8 weeks for ELISA assay of IL-1alpha. and IL-1beta. High repetition animals experienced a 2-fold decline in reach rate, strong emergence of a raking movement, and increased IL-1alpha. IL-1alpha decreased in the low repetition group. IL-1beta decreased in both groups. This model provides evidence that inflammation increases with repetition. At the higher reach rate, persistent IL-1alpha serum levels indicate chronic inflammation that is attenuated at the lower reach rate. These findings support the use of risk reduction in MSD prevention. Description provided by NIOSH
• Subjects:
  • Animals
  • Ergonomics
  • Laboratories
  • Musculoskeletal Diseases
  • Musculoskeletal System
  • Occupational Health
  • Safety
• Keywords:
  • Animal-studies
  • Laboratory-animals
  • Muscular-disorders
  • Musculoskeletal-system-disorders
  • Muscle-tissue
  • Muscle-function
  • Repetitive-work
  • Ergonomics
• ISBN:
  9780945289203
• ISSN:
  1071-1813
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Proceedings
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  46
• NIOSHTIC Number:
  nn:20023295
• Citation:
  Proceedings of the Human Factors and Ergonomics Society 46th Annual Meeting, September 29 - October 4, 2002, Baltimore, Maryland, Bringing Fundamentals & New Opportunities. Santa Monica, CA: Human Factors and Ergonomics Society, 2002 Sep; 46(Med Sys Rehab):1486-1490
• Federal Fiscal Year:
  2002
• Performing Organization:
  Temple University
• Peer Reviewed:
  True
• Start Date:
  20000601
• Source Full Name:
  Proceedings of the Human Factors and Ergonomics Society 46th Annual Meeting, September 29 - October 4, 2002, Baltimore, Maryland, Bringing Fundamentals & New Opportunities
• End Date:
  20120731
• Download URL:
  https://stacks.cdc.gov/view/cdc/195813/cdc_195813_DS1.pdf
• File Type:
  [PDF - 547.66 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d5092f963d3a3c88905747c2d056bf7ff35d0d9b827616323af6a4631e9e49f6d8fbd8091c351cfb8c339f967e0dc1395b58262e230ad3738999306e14b5b7ce